YOKOGAWA/INSILICO
Yokogawa Electric Corporation (TOKYO:6841) announces that it has acquired all shares of Insilico Biotechnology AG (“Insilico”), a Stuttgart, Germany-based developer and provider of bioprocess software and services. Fostering the development of the bioeconomy is one of the priority issues within Yokogawa’s sustainability goals, and in line with that the company aims to leverage this acquisition to build total bioprocess solutions that support biopharmaceutical development through to manufacturing.
Driven by developments such as the COVID-19 pandemic, demand continues to grow for biopharmaceuticals that have fewer side effects and can be used to treat patients with rare and intractable conditions. In contrast to the production of chemically synthesized general-purpose pharmaceuticals, the overall cost of biopharmaceuticals is higher, and the complex cell cultivation process required to efficiently and stably obtain the target proteins demands rigorous quality control measures that pose significant challenges with mass production.
The cells cultivated in a bioreactor are immense in number. As each of these cells generate the material that form the active ingredients in pharmaceuticals, it is necessary to monitor their individual metabolic reactions. The real-time visualization and analysis of any environmental factors such as changes in pH and dissolved oxygen concentration are also very important. As such, it has been extremely difficult to carry out cell production by controlling the complex cell reaction systems with a large number of set parameters.
Insilico’s digital twin technology uses an advanced hybrid model formed from a mechanistic model*1 of the unique characteristics of an intracellular metabolic network and a data-driven model*2 constructed from process data using the machine learning process. As well as drastically accelerating what until now has been a multiple-year development process, prediction and simulation also enable the acquisition of a deep understanding of the metabolism process. And given that this solution enables the construction of metabolism models for bacteria and many other kinds of cellular organisms, it can also be used in a wide variety of applications related to foods, chemicals, and other products that utilize biotechnology.
In manufacturing too, Insilico’s digital twin technology enables the real-time analysis of process data, which allows for the constant prediction of cultivation performance, the soft sensing of nutritional components that cannot be measured directly, and the early detection of process abnormalities and provision of guidance to operators. By deploying this problem-solving technology, product quality can be stabilized, which contributes to efficient mass production.
Klaus Mauch, CEO of Insilico Biotechnology AG, says: “There are high expectations for this fusion between our cutting-edge digital twin software technology for bioprocesses and Yokogawa’s pharmaceutical production system solutions. I believe that through Yokogawa’s global network we will be able to expand our sales channels and make a great contribution to the biopharmaceuticals industry.”
Hiroshi Nakao, a Yokogawa vice president and head of the company’s Life Business Headquarters, says: “I firmly believe that the innovative digital twin technology offered by Insilico, which has a proven track record with major biopharmaceutical companies, will accelerate digital transformation in the bioprocessing industry. We will leverage our engineering technology and develop our business with a view to the commercialization of bioprocesses.”
Overview of Insilico Biotechnology AG
- Established: 2001
- Location: Stuttgart, Germany
- CEO: Klaus Mauch
- Number of employees: 29
- Business: Development of digital twin-based software and provision of services for bioprocesses
- Website: https://www.insilico-biotechnology.com/
*1 Mechanistic model: A model that is developed based on the fundamental principles of the relevant reaction or mechanism, so a deep knowledge and understanding of the process is required to construct the model. The model that is obtained as a result has variables and parameters that can be physically interpreted, and advanced generalization is possible. However, a high precision physical model requires high development and computation costs.
*2 Data driven model: In contrast to mechanistic models, no knowledge of the fundamental principles of the relevant process is required. The advantages of this include simple implementation and relatively low development and computation costs. However, disadvantages include difficulties in interpreting data after forecasting or simulation is performed and generalizing results. Requiring large volumes of process data to construct the model is another drawback of this technique.
About Yokogawa
Yokogawa provides advanced solutions in the areas of measurement, control, and information to customers across a broad range of industries, including energy, chemicals, materials, pharmaceuticals, and food. Yokogawa addresses customer issues regarding the optimization of production, assets, and the supply chain with the effective application of digital technologies, enabling the transition to autonomous operations.
Founded in Tokyo in 1915, Yokogawa continues to work toward a sustainable society through its 17,500 employees in a global network of 119 companies spanning 61 countries.
For more information, visit www.yokogawa.com
The names of corporations, organizations, products, services and logos herein are either registered trademarks or trademarks of Yokogawa Electric Corporation, Insilico Biotechnology AG, or their respective holders.
View source version on businesswire.com: https://www.businesswire.com/news/home/20211102005399/en/
Link:
About Business Wire
Subscribe to releases from Business Wire
Subscribe to all the latest releases from Business Wire by registering your e-mail address below. You can unsubscribe at any time.
Latest releases from Business Wire
Belkin Achieves Qi2.2 Certification for Its Upcoming Products, Unlocking the Future of 25W Wireless Charging15.7.2025 19:06:00 CEST | Press release
With Qi2.2 certification, Belkin reinforces its commitment to quality, safety, and performance for the next generation of wireless charging Belkin, a leading consumer electronics brand for over 40 years, today announced it has received official Qi2.2 certification from the Wireless Power Consortium (WPC) for its upcoming products. As one of the first accessory brands to deliver Qi2.2-certified devices, Belkin is helping bring the next generation of wireless charging to market – enabling faster wireless charging speeds, broader compatibility, and improved performance for consumers. Belkin’s close partnership with the WPC since 2015 has been instrumental in bringing these advancements to consumers. As an early adopter and long-time contributor to WPC standards, Belkin was selected as one of a small group of trusted manufacturers to test and certify Qi2.2 products ahead of the broader industry rollout. All Belkin products undergo rigorous safety, quality, and performance testing. The comp
Cessna Grand Caravan EX to Feature New Executive Interior Options, Expanding Opportunities for Elevated Missions15.7.2025 18:05:00 CEST | Press release
The legendary Cessna Grand Caravan EX will now feature three new executive interior schemes for customers to select when designing their aircraft cabin. The Lunar, Obsidian and Saddle Sport interiors join the existing Canyon and Savanna schemes, providing a broader range of standard choices. The new interior options are available to customers starting this month and allow them to further tailor the interior of their aircraft based on their personal preference or mission. This press release features multimedia. View the full release here: https://www.businesswire.com/news/home/20250715021096/en/ Cessna Grand Caravan EX to feature new executive interior options, expanding opportunities for elevated missions (Photo Credit: Textron Aviation) The Cessna Grand Caravan EX is designed and manufactured by Textron Aviation Inc., a Textron Inc. (NYSE:TXT) company. Premium versions of each of the new interiors are also available, featuring quilted seat stitching and plush carpet, providing an elev
7 Million Tokens Sells Out in less than One Hour—$MBG Token Pre-Sale Shatters Expectations15.7.2025 17:27:00 CEST | Press release
MultiBank Group, the world’s largest and most regulated financial derivatives institution, has set a new benchmark in digital asset launches. The Group’s $MBG Token Pre-Sale sold out in less than one hour with all 7 million tokens fully subscribed across MultiBank.io and Uniswap. This press release features multimedia. View the full release here: https://www.businesswire.com/news/home/20250715055611/en/ The Group’s $MBG Token Pre-Sale sold out in less than one hour with all 7 million tokens fully subscribed across MultiBank.io and Uniswap. Commenting on the success of the Pre-Sale, Naser Taher, Founder and Chairman of MultiBank Group, said: “The sell-out of our initial $MBG Token offering in less than one hour is a decisive validation of our vision. In a market saturated with speculation, the response we received confirms that institutional-grade transparency, regulatory integrity, and asset-backed value are what investors are now demanding. $MBG is here for the long term, reflecting t
First Patient Enrolled in National Cancer Institute’s Vanguard Study Evaluating Guardant Health’s Shield Multi-Cancer Detection Test15.7.2025 17:01:00 CEST | Press release
Study addressing feasibility of using multi-cancer detection tests in future trials aims to enroll up to 24,000 participantsShield MCD reviewed by FDA as part of NCI’s investigational device exemption (IDE) Guardant Health, Inc. (Nasdaq: GH), a leading precision oncology company, today announced that patient enrollment has begun in the National Cancer Institute (NCI)’s Vanguard Study to evaluate emerging multi-cancer detection (MCD) technology. Guardant’s Shield™ MCD test was selected for use in the four-year study, which aims to enroll up to 24,000 patients and evaluate the use of MCD tests—blood tests that can screen for several types of cancer simultaneously—in future randomized controlled trials. Guardant’s Shield MCD test was chosen for the study based on the overall performance of its Shield platform in detecting 10 cancer types, including lung, breast, colorectal, prostate, bladder, ovarian, pancreatic, esophageal, liver and gastric. The data were presented at the 2025 American
Deltatre Announces Acquisition of Endeavor Streaming to Create Digital and Streaming Platform Leader15.7.2025 16:15:00 CEST | Press release
Deltatre, a leading international provider of streaming, digital, data, and graphics solutions for the sports, media, and entertainment industries, today announced it has entered into a definitive agreement to acquire Endeavor Streaming from Endeavor Group Holdings, Inc. This press release features multimedia. View the full release here: https://www.businesswire.com/news/home/20250715833650/en/ Deltatre announces acquisition of Endeavor Streaming. In bringing together these complementary and proven digital and OTT providers, Deltatre is joining its advanced product suite – D3 VOLT, FORGE, AXIS, and DIVA, which delivers multi-functional digital experiences with integrated video – with Endeavor Streaming’s pure-play OTT product, VESPER. They will also unite their digital strategy, consulting, and direct-to-consumer growth marketing services. The combined business will be best equipped to deliver for sports, media, and entertainment clients through a compelling and comprehensive range of
In our pressroom you can read all our latest releases, find our press contacts, images, documents and other relevant information about us.
Visit our pressroom