LifeSpan BioSciences Releases Best-In-Class PathPlus™ Top Performing Immunohistochemistry Antibodies for Cancer Targets
LifeSpan BioSciences, Inc. (LSBio™), the industry leader in molecular pathology, today announced the first release of its PathPlus™ series of antibodies. These 565 antibodies were selected from among thousands tested and identified to be the best performing reagents for immunohistochemical detection of 200 high-value cancer targets in formalin-fixed paraffin-embedded human tissues.
Antibody validation has become an industry roadblock as thousands of antibodies have become available to customers who face difficult choices in determining which antibodies are the best performers for each application, including immunohistochemistry, flow cytometry, ELISA, Western blot, or immunofluorescence. Antibodies that perform well in one assay, such as IHC, may not be the most specific reagent for another assay, such as flow cytometry.
“Identifying the optimal reagents to use in their experiments is a pain point for researchers,” said LSBio CEO Heather Holemon. “There is a tremendous need to identify the best performers in every application from among the hundreds of antibodies that are currently available to each target.”
LSBio has initiated a program to systematically identify the best performing antibodies in each application. Its initial focus is to identify those antibodies that are the best performers in immunohistochemistry on formalin-fixed paraffin-embedded tissues. With a tissue archive of over two million samples, and more than 20 years’ experience performing IHC for pharma and biotech customers, LSBio is uniquely qualified to determine which reagents are the best-in class.
Immunohistochemistry, which is the technique used by pathologists to classify tumors, is a powerful method of antibody validation because it can be used to visualize the binding of an antibody to individual cell types within complex tissues and to subcellular structures within cells such as nuclei or cell membranes. Comparing the specific binding characteristics of multiple antibodies to the same target allows LSBio to identify those that have the highest degree of specificity and least nonspecific staining.
LSBio uses a stringent validation protocol that involves blinded IHC testing of up to 20 different antibodies to a target protein on a tissue microarray containing 21 different human tissue types. The results for each antibody are analyzed and compared in order to rank them by performance. Those antibodies that show the highest specificity and least nonspecific staining on formalin-fixed paraffin-embedded tissues are offered under the PathPlus™ brand.
“We have a unique opportunity to leverage our leadership position in antibody validation to set the standard for providing high-quality IHC antibodies to the research and pharmaceutical communities,” said Glenna Burmer, M.D., Ph.D., Chief Scientific Officer of LifeSpan. “We plan to offer multiple series of PathPlus™ validated reagents as we evaluate antibodies to the most important targets in the human genome.”
About LifeSpan BioSciences, Inc.
LifeSpan BioSciences is the industry leader in providing IHC validated reagent antibodies and services to the global community of academic, pharmaceutical and biotech researchers. LSBio has built a catalog of more than 750,000 reagent antibodies, assay kits, proteins, and biochemicals that it sells through a network of international distributors. For more information, visit https://www.lsbio.com/
About Business Wire
101 California Street, 20th Floor
CA 94111 San Francisco
Subscribe to releases from Business Wire
Subscribe to all the latest releases from Business Wire by registering your e-mail address below. You can unsubscribe at any time.
Latest releases from Business Wire
NY-CITIGROUP5.12.2019 19:32:13 CET | Press release
Citi Private Bank Issues Outlook 2020: Global Growth Can Endure Over the Coming Year
MA-KANGURU5.12.2019 17:33:11 CET | Press release
Kanguru Leaps Over The Competition With A New OS Agnostic Encrypted Fingerprint Access Flash Drive
MD-PROMETRIC5.12.2019 15:02:46 CET | Press release
SHRM--Society for Human Resource Management and Prometric Renew Long-Term Partnership with Multi-year Agreement
SC-SENSOR-ELECTRONIC5.12.2019 15:02:06 CET | Press release
Sensor Electronic Technology Obtains Permanent Injunction Against U.S. UV LED Companies
SARTORIUS5.12.2019 14:21:05 CET | Press release
Sartorius Acquires a Majority Stake in Cell Culture Media Specialist Biological Industries
CT-PW-POWER-SYSTEMS5.12.2019 14:08:05 CET | Press release
PW Power Systems Delivers Brighter Holidays for Puerto Rico
In our pressroom you can read all our latest releases, find our press contacts, images, documents and other relevant information about us.Visit our pressroom