VALBIOTIS
12.6.2020 07:37:10 CEST | Business Wire | Press release
VALBIOTIS (Paris:ALVAL) (FR0013254851 - ALVAL / PEA/SME eligible), a Research & Development company committed to scientific innovation for preventing and combating metabolic diseases, announces that the main results of its international Phase II clinical study demonstrating the metabolic benefits of TOTUM-63 in prediabetic patients are being presented at the 80th Scientific Sessions of the American Diabetes Association (ADA).
This is the fourth time that VALBIOTIS has had its work on TOTUM-63 selected by this major congress, which is being held from 12 to 16 June this year - in virtual format, due to the COVID-19 health crisis. TOTUM-63's clinical data on carbohydrate metabolism, weight and waist circumference are presented as an e-poster (www.valbiotis.com/en/scientific-publications ). The presentation to the ADA serves as recognition by the global scientific community of the quality of the results obtained for a groundbreaking treatment to reduce the risk of developing type 2 diabetes. No clinically proven answer exists today for people with prediabetes, a reversible state of impaired glucose metabolism which, without intervention, has a 70 to 90% risk of developing into type 2 diabetes1 .
The positive results of this study were announced in two stages (press releases of 3 July 2019 and 2 September 2019 ). In order to confirm these results on a larger population and to allow healthcare professionals worldwide access to this scientific innovation, VALBIOTIS entered into a global strategic partnership with Nestlé Health Science in early 2020. This agreement covers the development and marketing of TOTUM-63 (press release of 5 February 2020 ), an innovative and patented combination of five plant extracts.
Prof. Jean-Marie Bard, Hospital Practitioner and Professor of Fundamental and Clinical Biochemistry at the University of Nantes, scientific advisor for the study comments: "The presentation of these results to the ADA marks both a real turning point in health nutrition and the recognition of the clinical efficacy of TOTUM-63. This randomized, placebo-controlled Phase II study showed a significant reduction in fasting blood glucose, its primary endpoint, as well as a significant improvement in glucose tolerance, body weight and waist circumference, secondary endpoints of the study, all known as critical risk factors for developing type 2 diabetes. The data is remarkable for its consistency and the clear metabolic impact demonstrated in 51 subjects, all with abdominal obesity associated with moderate hyperglycemia, 2-hour hyperglycemia (OGTT) and hypertriglyceridemia."
At the end of the 6-month supplementation period, fasting blood glucose levels were significantly reduced in subjects receiving 5 grams per day of TOTUM-63 compared to subjects in the control group receiving 5 grams of placebo (-0.04 ± 0.02 vs. +0.09 ± 0.04 g/L, p<0.05). TOTUM-63 also significantly reduced two-hour blood glucose, or postmeal blood glucose (-0.02 ± 0.07 vs +0.32 ± 0.17 g/L, p<0.05), body weight (-0.07 ± 0.42 vs +1.83 ± 0.57 kg; p<0.05) and waist circumference (-1.67 ± 0.73 vs +2.81 ± 0.65 cm; p<0.001).
These results place TOTUM-63 as the first clinically approved, already marketable product for prediabetic individuals (nearly 1 billion worldwide2 ) to reduce the risk of developing type 2 diabetes.
Murielle Cazaubiel, Member of the Management Board, Director of Development and Medical Affairs at Valbiotis, declares: "Participating in the ADA is part of an outstanding series of achievements for VALBIOTIS' flagship prediabetes product. In just over a year, TOTUM-63 has been successfully scaled up to industrial production and confirmed its clinical efficacy on several metabolic targets and a number of cardiovascular risk factors. It is now the subject of a global partnership with a major player in the field of health nutrition, responsible for the final phase of its development. The international Phase II/III clinical trial REVERSE-IT (press release of 2 April 2020 ) co-conducted with Nestlé Health Science will start this year with 600 participants. This trial is designed not only to confirm the positive Phase II results on fasting blood glucose levels, but also to extend evaluation of TOTUM-63 to untreated type 2 diabetics."
ABOUT VALBIOTIS
VALBIOTIS is a Research & Development company committed to scientific innovation for preventing and combating metabolic diseases in response to unmet medical needs.
VALBIOTIS has adopted an innovative approach, aiming to revolutionize healthcare by developing a new class of nutritional health solutions designed to reduce the risk of major metabolic diseases, based on a multi-target approach and made possible by the use of plant-based ingredients.
Its products are intended to be licensed to players in the health world.
VALBIOTIS was founded in La Rochelle in early 2014 and has formed numerous partnerships with top academic centers. The Company has established three sites in France – Périgny, La Rochelle (17) and Riom (63).
VALBIOTIS is a member of the “BPI Excellence” network and received “Innovative Company“ status awarded by BPI France. Valbiotis has also been awarded “Young Innovative Company” status and has received major financial support from the European Union for its research programs via the European Regional Development Fund (ERDF). VALBIOTIS is a PEA-SME eligible company.
Find out more about VALBIOTIS: www.valbiotis.com
Name: VALBIOTIS
ISIN code: FR0013254851
Mnemonic code : ALVAL
DISCLAIMER
This press release contains forward-looking statements about VALBIOTIS’ objectives, based on rational hypotheses and the information available to the company at the present time. However, in no way does this constitute a guarantee of future performance, and these projections may be reconsidered based on changes in economic conditions and financial markets, as well as a certain number of risks and uncertainties, including those described in the VALBIOTIS registration document, filed with the French Financial Markets Regulator (AMF) on 31 July 2019 (application number R19-030) as well in its supplement approved by the AMF on 9 October 2019. These documents are available on the Company’s website (www.valbiotis.com ).
This press release, as well as the information contained herein, does not constitute an offer to sell or subscribe to, or a solicitation to purchase or subscribe to, VALBIOTIS’ shares or securities in any country.
1
Tabak AJ. et al., Lancet, 2012
2
AEC Partners data
View source version on businesswire.com: https://www.businesswire.com/news/home/20200611005792/en/
Link:
About Business Wire
Subscribe to releases from Business Wire
Subscribe to all the latest releases from Business Wire by registering your e-mail address below. You can unsubscribe at any time.
Latest releases from Business Wire
Dreamstime Adds Ten More Language Versions, Reaching 23 in Total29.1.2026 13:00:00 CET | Press release
Dreamstime, the world’s largest stock photography community, announced today the addition of new language versions—Czech, Japanese, Korean, Hindi, Turkish, Indonesian, Danish, and Norwegian—to expand its global reach and provide a more comprehensive digital experience worldwide. Hebrew and Arabic will be launched next. Key Takeaways: Dreamstime expands into 23 languages, increasing global reach and accessibility. AI-powered translation improves search relevance, onboarding, and cultural discovery. With billions of new pages and coverage in almost every country worldwide in native, official, or very popular languages, this is Dreamstime’s most prolific launch in its 25-year history. The platform already operates in 13 languages: English, French, Polish, Italian, Spanish, Portuguese, Dutch, Russian, Greek, Chinese, Swedish, German, and Romanian. With a stock photography collection of over 350 million files and millions of new items added monthly, Dreamstime manages a constantly growing d
NIQ Launches Breakthrough Framework That Exposes Billions Lost to the Say–Do Gap29.1.2026 13:00:00 CET | Press release
The new global framework quantifies the disconnect between consumer intent and real‑world buying behavior, unlocking powerful paths to reclaim volume and fuel growth NielsenIQ (NYSE: NIQ) today announced the launch of its Say–Do Gap Measurement Framework, an innovative behavioral metric set to transform how brands and retailers understand modern consumers and navigate a pressing challenge: consumers who say one thing but buy another. With economic uncertainty, shifting priorities, and increasingly value‑driven decision-making changing consumer habits, this growing disconnect has cost the industry more than 13 billion unit sales over the past five years—losses many companies can no longer afford to overlook. By unifying deep attitudinal insights with verified purchase data across 25+ global markets, the Say–Do Framework bridges this gap and exposes where brands are losing momentum, where unmet demand is hiding, and where opportunity is silently compounding. Brands and retailers can now
IDDI Reveals New Brand & Celebrates 35 Years of Clinical Data Science Excellence29.1.2026 13:00:00 CET | Press release
IDDI, a global clinical data science partner with more than 35 years of proven quality, today announced the launch of its refreshed brand. The new brand highlights the company’s continued focus on patients and commitment to innovation while honoring its legacy of scientific rigor. The launch coincides with IDDI’s 35-year anniversary and will debut publicly at the SCOPE Summit on Feb. 2, 2026. Biomedical research is shifting toward more complex trials and advanced analytics. But, as one survey revealed, only 46% of life science leaders are fully confident their organization’s data are consistently available and accurate. IDDI’s new brand reinforces that their services are the solution, explaining how they deliver high-quality data and mitigate risk from design to registration and beyond. “Reaching 35 years is an important milestone, not only because of our longevity, but because of the impact we’ve had,” said Marc Buyse, ScD, founder and CEO of IDDI. “Our new brand reflects the heart of
Media Release: Jannik Sinner and Allianz Announce Multi-Year Global Partnership29.1.2026 11:04:00 CET | Press release
Jannik Sinner becomes Global Brand Ambassador of the world’s most valuable insurance brand.The partnership broadens Allianz’s established sports collaborations; the large tennis fan base worldwide will drive emotional engagement with Allianz.“We’re here to serve” captures the spirit of both partners; joint projects with The Jannik Sinner Foundation aim to support children’s future. Tennis star Jannik Sinner and Allianz Group announced a multi-year global partnership today, with the leading insurer and asset manager becoming an official partner of the four-time Grand Slam champion. Boasting approximately 300 million fans worldwide and a billion-strong ATP global fan base, tennis is the second-most popular sport behind football across Allianz key markets. A cornerstone of the collaboration is empowering children and youth through education and sport, providing them with enhanced opportunities for growth, health, and future success. This partnership also expands Allianz's involvement in s
How Aker Security Builds Control Rooms for Real-Time Decision-Making29.1.2026 10:00:00 CET | Press release
In a new case, Aker Security demonstrates how a control room built on Cyviz’ technology platform functions as the operational nerve center for decision-making, collaboration, and preparedness. In today’s security landscape, the challenge lies in aggregating, visualizing, and using large volumes of data effectively in situations where time, precision, and coordination are critical. This press release features multimedia. View the full release here: https://www.businesswire.com/news/home/20260129578139/en/ GSOC Aker Security oversees security and preparedness for large parts of the Group, covering several thousand employees. Its services include travel security, global event and incident monitoring, crisis management, and security advisory services. "We approached Cyviz because we needed a solution that could bring everything together on a single platform, while at the same time supporting the way we actually work operationally," says Tonje Evensen Bråthen, Head of the Global Security Op
In our pressroom you can read all our latest releases, find our press contacts, images, documents and other relevant information about us.
Visit our pressroom