Business Wire

LUNG-AMBITION-ALLIANCE

Share
The Lung Ambition Alliance: Nearly One Quarter of Deaths From Lung Cancer Could Be Avoided in High-Risk Populations Through Targeted Lung Cancer Screening Worldwide

A report published today, ‘Lung Cancer Screening: The Cost of Inaction’ , shows that lung cancer screening presents a critical opportunity to significantly improve survival.1 Nearly one quarter of deaths from lung cancer could be avoided in high-risk populations through the adoption of targeted screening with low-dose computed tomography (LDCT) scans, as based on the results of the NELSON study.2 The study in over 13,000 people found that in a European high-risk population deaths were reduced by screening with LDCT scans to 18.4% of total deaths compared to 24.4% in the control arm after ten years’ follow-up.

Lung cancer causes 1.8 million deaths per year and carries the greatest economic burden of all cancers, costing €18.8 billion per year* in Europe alone.3,4 Developed for the Lung Ambition Alliance, the new report found that large-scale implementation of targeted screening using LDCT scans can significantly reduce this cost burden and improve survival for patients – by increasing the number of lung cancers found at early stages where there is better prognosis and more treatment options are available.

Currently, only around one in five patients worldwide are diagnosed at Stage I, where they have between a 68-92% chance of surviving five years – compared with under just 10% when diagnosed at Stage IV. 5,6,7 Early-stage lung cancer can be managed with less complex, less costly clinical pathways than when it is diagnosed at later stages, allowing significant cost savings to be realised through early diagnosis.8,9,10 As lung cancer progresses, healthcare costs rise from increased frequency of hospital admissions, additional rounds of treatment, additional care requirements and greater likelihood of palliative care.11

Earlier diagnosis also reduces lost productivity from cancer overall, as more patients and carers can remain active and in some cases their cancer becomes a treatable condition rather than a fatal one.10 In Europe, productivity loss from premature mortality from lung cancer costs almost €10 billion every year.3

Professor Giorgio Scagliotti, Past President and Interim Chief Science Officer of IASLC, Professor of Medical Oncology at the University of Turin School of Medicine, Italy, said: “Everyone with lung cancer deserves care that offers the greatest chance of early detection and improved survival. The evidence from large-scale randomized clinical trials is indisputable: targeted, low-dose CT screening has the potential to save patients’ lives. Today is the second anniversary of the Lung Ambition Alliance, and while treatment for lung cancer has come so far, to realize the full potential of these advances we need to ensure people have timely access to effective screening and diagnosis – which would allow them to act quickly on possible cancer symptoms.”

Fewer screens are required to prevent one lung cancer death than for other cancer types. The NELSON study found that for every 320 LDCT scans administered, one life could be saved, compared to 864 tests for colorectal cancer and between 645 to 1,724 scans for breast cancer. 12 ,13,14 However, screening for lung cancer is not as widely available as for breast and colorectal cancers.15

Unfortunately for lung cancer screening, policy change has lagged behind the changing attitudes as new evidence has become available. In a survey of policymakers in seven countries (France, Germany, Italy, Japan, Spain, UK, US), the majority (75%) believed that countries should invest in targeted lung cancer screening programs.16 Only a few countries across the world have committed to introducing nationwide screening programs, these include the US, Japan, South Korea, Croatia, Poland and Australia.1 The report calls on governments to implement LDCT screening at scale in high-risk populations and provides implementation guidance based on decades of global research.

Mohit Manrao, Vice President and Global Franchise Head of Lung Cancer, AstraZeneca, said: “We cannot squander the opportunity to alleviate the burden of lung cancer on society through effective screening. Not only will early detection benefit patients, but this approach also has the potential to reduce costs for health systems, ensure greater sustainability in the long run and support governments in achieving their goals of reducing cancer mortality as a whole. Early diagnosis is key to achieving the best possible outcomes for lung cancer patients. We now have a deeper understanding of the complexities of lung cancer and how to treat it, and indeed an imperative to provide patients with care that is best suited to the characteristics of their disease.”

About the Lung Ambition Alliance

The Lung Ambition Alliance is a flagship partnership of diverse organizations united in the quest to eliminate lung cancer as a cause of death. The Alliance aims to accelerate progress and bring meaningful change for lung cancer patients by amplifying the expertise of each partner and prioritizing meaningful projects with potential to further its goal. The founding partners – the International Association for the Study of Lung Cancer (IASLC), Guardant Health, the Global Lung Cancer Coalition (GLCC) and AstraZeneca – will explore and overcome barriers to screening and early diagnosis, the development of innovative medicine and quality care, and pursue an ambitious vision for the future in lung cancer that starts with doubling five-year survival by 2025.

For more information, visit www.lungambitionalliance.org .

References

_____________________________
* The cost of lung cancer in the EU in 2009
1 The Health Policy Partnership. Lung cancer screening: the cost of inaction report. June 2021
2 de Koning h.J., et al. Reduced Lung-Cancer Mortality with Volume CT Screening in a Randomized Trial. NEJM. 2020,382:503-513
3 Ferlay J, Ervik, M, Lam, F, Colombet, M, Mery, L, Piñeros, M, Znaor, A, Soerjomataram, I, Bray, F,. Global cancer observatory: cancer today. Available from: https://gco.iarc.fr/today . Accessed June 2021.
4 Luengo-Fernandez R, Leal J, Gray A, et al. 2013. Economic burden of cancer across the European Union: a population-based cost analysis. The Lancet Oncology 14(12): 1165-74
5 Goldstraw P, Chansky K, Crowley J, et al. 2016. The IASLC lung cancer staging project: proposals for revision of the TNM stage groupings in the forthcoming (eighth) edition of the TNM classification for lung cancer. Journal of Thoracic Oncology 11(1): 39-51
6 Heist RS, Engelman JA. 2012. SnapShot: non-small cell lung cancer. Cancer cell 21(3): 448.e2
7 Public Health England, National Cancer Registration & Analysis Service. Staging data in England. Available from: https://www.cancerdata.nhs.uk/stage_at_diagnosis . Accessed June 2021.
8 Lung Cancer Europe. 2019. Early diagnosis and screening challenges in lung cancer. Bern: Lung Cancer Europe
9 Arrieta O, Quintana-Carrillo RH, Ahumada-Curiel G, et al. 2014. Medical care costs incurred by patients with smoking-related non-small cell lung cancer treated at the National Cancer Institute of Mexico. Tobacco Induced Diseases 12(1):25
10 ten Haaf K, Tammemägi MC, Bondy SJ, et al. 2017. Performance and Cost-Effectiveness of Computed Tomography Lung Cancer Screening Scenarios in a Population-Based Setting: A Microsimulation Modeling Analysis in Ontario, Canada. PLOS Medicine 14(2): e1002225
11 Wood et al. (2019). Cost burden associated with advanced non-small cell lung cancer in Europe and influence of disease stage. BMC Cancer 19, 214 (2019). https://doi.org/10.1186/s12885-019-5428-4 . Accessed June 2021.
12 Aberle DR, Adams AM, Berg CD, et al. 2011. Reduced lung-cancer mortality with low-dose computed tomographic screening. New England Journal of Medicine 365(5): 395-409
13 The Canadian Taskforce for Preventive Health Care. 2018. Breast cancer update: 1000 person tool. Calgary: CTFPHC
14 Fitzpatrick-Lewis D, Ali MU, Warren R, et al. 2016. Screening for colorectal cancer: A systematic review and meta-analysis. Clinical Colorectal Cancer 15(4): 298-313
15 Cancer Treatment Centers of America. Lung Cancer Screening Should Be More Common . Available at: https://www.cancercenter.com/community/blog/2017/11/screening-for-lung-cancer-like-we-do-for-colon-and-breast-cancer [Accessed July 2021].
16 YouGov survey: Lung Cancer Policymaker Polling. April 2021. AZ Data on File.

Link:

ClickThru

About Business Wire

Business Wire
Business Wire
101 California Street, 20th Floor
CA 94111 San Francisco

http://businesswire.com

Subscribe to releases from Business Wire

Subscribe to all the latest releases from Business Wire by registering your e-mail address below. You can unsubscribe at any time.

Latest releases from Business Wire

SCENTMATIC's AI "KAORIUM" Debuts at THAMEEN Fragrance Launch in London's Selfridges4.7.2025 11:13:00 CEST | Press release

SCENTMATIC Inc., a leader in scent digitalization, introduced its AI-powered scent-to-language system, KAORIUM, at the THAMEEN Fragrance new product launch event. This pivotal event took place from June 5 to 11, 2025, at Selfridges department store in London, UK. This press release features multimedia. View the full release here: https://www.businesswire.com/news/home/20250703662207/en/ State of exhibition Global Expansion: KAORIUM Establishes UK Presence Europe leads the global fragrance market, with the UK projected to reach US$2.82 billion by 2033. Recognizing this, SCENTMATIC is rapidly expanding its international footprint. In May 2024, SCENTMATIC established its overseas subsidiary, KAORIUM, in London, appointing industry expert Ben Yanoushek as CEO. Official UK operations commenced on February 1, 2025, with the launch of its dedicated website: www.kaorium.com. KAORIUM Trialed at "Florentine Diamond" Launch Event The "Florentine Diamond" launch event for luxury brand THAMEEN Frag

Andersen Consulting samarbejder med Mercurial Minds om at forbedre mulighederne inden for digital transformation4.7.2025 01:10:00 CEST | Pressemeddelelse

Andersen Consulting udvider sit udbud af teknologidrevne løsninger med tilføjelsen af samarbejdsfirmaet Mercurial Minds (M.M.), et konsulentfirma inden for digital transformation, AI og IT med base i Pakistan. M.M. blev grundlagt i 2013 og tilbyder en række tjenester, der er designet til at hjælpe organisationer med at udvikle sig og skalere, herunder i forbindelse med deres digitale transformationsstrategi, AI-tjenester, it-rådgivning og udvikling af robuste mobil- og webbrugeroplevelser. Firmaet leverer end-to-end-løsninger – udformning af datadrevne køreplaner, udvikling af intelligent automatisering og levering af sikre mobil- og weboplevelser, der kan skaleres – skræddersyet til virksomheder, der ønsker at forbedre sine forbindelsesmulighederne og opnå indsigter i realtid. M.M. betjener en bred vifte af brancher med fokus på finans, telekommunikation og andre dataintensive sektorer. "Dette samarbejde er en katalysator," siger Nabeel Saiyer, administrerende direktør for M.M. "Vores

Global Tourism Surging Ahead of Economic Growth, With Visits to Hit 30 Billion by 20344.7.2025 01:00:00 CEST | Press release

The World Economic Forum report, in collaboration with Kearney and the Ministry of Tourism Saudi Arabia, predicts a significant uptick in tourist trips across the globeThe tourism sector will contribute $16 trillion to global GDP (more than 11% of the global economy) by 2034, according to World Travel & Tourism Council estimates (WTTC)India and China will be responsible for more than 25% of all outbound travel by 2030 The World Economic Forum has today published a new report forecasting that the travel and tourism industry is projected to serve 30 billion tourist trips by 2034. Travel and Tourism at a Turning Point: Principles for Transformative Growth, produced in collaboration with Kearney and the Ministry of Tourism Saudi Arabia, reveals a projected $16 trillion contribution to global GDP by the same year—representing more than 11% of the total world economy, according to World Travel & Tourism Council estimates. The report also found that the sector is expanding 1.5 times faster th

The 2025-2026 World Branding Awards Animalis Edition Honouring Leading Pet and Animal Brands Globally3.7.2025 21:00:00 CEST | Press release

The 2025-2026 World Branding Awards Animalis Edition marked its fifth instalment, bringing together leading pet and animal brands from all around the world. These brands were celebrated for their outstanding achievements, earning recognition as National, Regional, and Global Winners. The awards ceremony, held at Vienna's prestigious Hofburg Palace, welcomed winners across diverse categories, including pet food, retail, wellness, pet exhibitions, and aquatic products. Mounia Berrada-Gouzi expertly hosted the evening, which culminated in a grand celebration of brand excellence. “The Animalis Edition of the World Branding Awards recognises brands that have achieved the highest distinction—genuine recognition in the hearts and minds of consumers. Tonight, we honour those whose names resonate globally, whose values inspire loyalty, and whose presence defines excellence in the pet and animal industry,” said Richard Rowles, Chairman of the World Branding Forum. Out of over 950 brands nominate

Venture Global Announces 20-Year Sales and Purchase Agreement with PETRONAS3.7.2025 14:59:00 CEST | Press release

Today, Venture Global, Inc. (NYSE: VG) announced the execution of a new 20-year Sales and Purchase Agreement (SPA) with PETRONAS LNG Ltd. (PLL), a subsidiary of the Malaysian state-owned oil and gas company, PETRONAS. Under the terms of the SPA, PETRONAS will purchase 1 million tonnes per annum (MTPA) of liquefied natural gas (LNG) from Venture Global’s third facility, CP2 LNG, for 20 years. This builds upon Venture Global’s existing agreement with PETRONAS for 1 MTPA of LNG supply from Plaquemines LNG. PETRONAS, a world-class partner in the LNG industry, joins other CP2 LNG customers in Europe, Asia and the rest of the world in a strategically important project to global energy supply and security. To date, approximately 10.75 MTPA of the 14.4 MTPA nameplate capacity for CP2 Phase One has been sold. About Venture Global Venture Global is a long-term, low-cost provider of U.S. LNG sourced from resource rich North American natural gas basins. Venture Global’s business includes assets ac

In our pressroom you can read all our latest releases, find our press contacts, images, documents and other relevant information about us.

Visit our pressroom
World GlobeA line styled icon from Orion Icon Library.HiddenA line styled icon from Orion Icon Library.Eye