LINTONPHARM
1.12.2021 14:02:14 CET | Business Wire | Press release
LintonPharm Co., Ltd., a China-based clinical stage biopharmaceutical company focused on the development of T cell engaging bispecific antibodies for cancer immunotherapy, today announced that the first patient has been dosed in the Company’s Phase 1/2 clinical trial program for catumaxomab (clinicaltrials.gov: NCT04799847 ), a monoclonal bispecific antibody being studied for the treatment of Non-Muscle-Invasive Bladder Cancer (NMIBC) unresponsive to Bacillus Calmette-Guerin (BCG).
“The initiation of our Phase 1 trial of catumaxomab for the treatment of NMIBC is an important step in our clinical program evaluating catumaxomab as targeted therapy in a broad range of cancers”, said Robert Li, PH.D., DABT, Co-founder and CEO of LintonPharm. “Patients with NMIBC BCG failure need new therapies due to the limitations of current treatments which bring poor prognosis, such as high rates of tumor recurrence, bladder dysfunction and lifelong intervention. Based on encouraging pre-clinical data and clinical experience with patients who’ve received catumaxomab in the past through the compassionate use program, we are hopeful that catumaxomab will be a very promising immunotherapy candidate for patients with NMIBC BCG failure.”
A recent publication indicated clinical benefits of catumaxomab as compassionate use in patients with EpCAM-positive recurrent NMIBC. It is noted that catumaxomab was well tolerated and presented promising performance in tumor control [1] . Based on the data and the developmental potential, catumaxomab could provide a feasible, safe, and efficacious therapy for NMIBC patients, if approved.
Bladder cancer is the 10th most commonly diagnosed cancer worldwide, with approximately 573,000 new cases in 2020 and roughly 75 percent are diagnosed as NMIBC [2][3] . Currently, the mainstay treatments of NMIBC include transurethral resection, chemotherapy and intravesical BCG [3] .
About Catumaxomab
Catumaxomab was approved by the European Medicines Agency in 2009 for the treatment of malignant ascites. This bispecific antibody binds to a transmembrane glycoprotein on the tumor cell--the epithelial cell adhesion molecule (EpCAM)--and CD3 on the T cell, and also recruits immune accessory cells through FcγR binding. Catumaxomab destroys tumor cells by engaging T cell and accessory cell mediated cytotoxicity and has the potential to induce long-term vaccinal effects which has been verified in animal models.
Recently, catumaxomab was authorized by regulatory authorities in China, Taiwan (China) and South Korea to conduct a global Phase 3 clinical trial for treating patients with advanced gastric cancer (clinicaltrials.gov: NCT04222114 ).
About LintonPharm
LintonPharm Co., Ltd. is a clinical-stage, research-oriented biopharmaceutical company committed to developing innovative T cell engaging bispecific antibodies with the goal of turning malignant cancers into manageable and possibly curable diseases. LintonPharm has developed multiple bispecific antibody platforms with a great potential of refined safety and efficacy profiles, long-lasting vaccinal effects and CMC efficiency. The current pipeline includes several treatments in development for blood cancer and solid tumors. The leading molecule, catumaxomab is being evaluated in clinical trials for both advanced gastric cancer and non-muscle invasive bladder cancer. For more information, please visit www.lintonpharm.com .
[1]. Ruf P, Bauer HW, Schoberth A, Kellermann C, Lindhofer H (2021). First time intravesically administered trifunctional antibody catumaxomab in patients with recurrent non muscle invasive bladder cancer indicates high tolerability and local immunological activity. Cancer Immunology, Immunotherapy. http://doi.org/10.1007/s00262-021-02930-7 |
[2]. World Health Organization (WHO). Globocan 2020. Global Cancer Observatory. Accessed January 7, 2021. https://gco.iarc.fr/ |
[3]. Kamat AM, Hahn NM, Efstathiou JA, et al. (2016) Bladder cancer. Lancet 2016. 388: 2796-810. http://dx.doi.org/10.1016/S0140-6736(16)30512-8 |
View source version on businesswire.com: https://www.businesswire.com/news/home/20211201005307/en/
Link:
About Business Wire
Subscribe to releases from Business Wire
Subscribe to all the latest releases from Business Wire by registering your e-mail address below. You can unsubscribe at any time.
Latest releases from Business Wire
Quorum Software Acquires Streamba to Extend Leadership as the AI Platform for the Energy Value Chain25.6.2026 16:35:00 CEST | Press release
Acquisition brings Streamba's AI-native logistics platform and VOR intelligence layer into Quorum’s unified energy data – closing the loop between planning, field execution and supply chain in real time Quorum Software, a global leader in energy software, today announced the acquisition of Streamba, an AI-native supply chain platform purpose-built for energy. This acquisition advances Quorum's position as the AI platform for the energy industry — embedding intelligent, real-time orchestration across upstream, midstream, measurement, SCADA and supply chain. For the first time, energy operators can connect planning, execution and back office in a single, AI-powered system. Quorum has built a comprehensive energy software platform through sustained innovation and strategic acquisitions, spanning planning, production operations, measurement, accounting, hydrocarbon management and logistics. Streamba’s Visibility, Orchestration and Response (VOR) platform adds a centralized operational inte
Clearwater Analytics Completes $8.4 Billion Take-Private Acquisition by Permira and Warburg Pincus25.6.2026 16:07:00 CEST | Press release
Acquisition supported by Francisco Partners, with participation from TemasekStockholders receive $24.55 per share Clearwater Analytics (“CWAN”, “Clearwater” or the “Company”), today announced the completion of its previously announced acquisition, a transaction valued at approximately $8.4 billion, by a Permira and Warburg Pincus-led Investor Group (the “Investor Group”). The transaction was supported by Francisco Partners, with participation from Temasek. With the completion of the acquisition, Clearwater’s Class A common stock no longer trades on the New York Stock Exchange. Under the terms of the agreement, Clearwater stockholders received $24.55 per share in cash, representing an approximately 47% premium over the Company’s undisturbed share price on November 10, 2025, the last trading day prior to media reports regarding a potential transaction. The transaction followed a thorough review process overseen by a Special Committee of independent and disinterested members of the Clearw
Visa Redefines Its Role in Travel With the Global Launch of Visa Destinations25.6.2026 16:00:00 CEST | Press release
A new consumer Visa travel platform is now live across 10 locations, including flagship cities such as Paris, London and New York City, with more destinations to be added later this year.This platform connects Visa cardholders with curated experiences and exclusive access aligned to passion-led travel pillars through a consumer mobile-first platform.Global anchor partners include Santander Group, Global Blue, Star Alliance, and Trip.com Group, leaders across the financial and travel ecosystem. Visa (NYSE: V), a global leader in digital payments, today announced the launch of Visa Destinations, a passion-led travel platform live in 10 major locations around the world, as the company redefines its role in the rapidly growing experience-driven travel economy. The move marks a strategic expansion of Visa’s role beyond payments, positioning the company at the center of how travelers discover, plan and experience trips. According to Visa research, travelers are increasingly choosing destinat
Incode Acquires Identiq to Expand Its Privacy-First Architecture for Identity and Fraud Prevention25.6.2026 15:00:00 CEST | Press release
Extends its privacy-by-design architecture with Identiq’s patented cryptographic technology that enables organizations to share fraud signals without sharing sensitive data. Incode Technologies, a global leader in AI-powered identity verification and fraud prevention, today announced that it has completed the acquisition of Identiq, a company specializing in privacy-enhancing cryptographic solutions for peer-to-peer anti-fraud collaboration. Incode announced this acquisition as part of a $100 million commitment to advancing its original privacy-preserving identity infrastructure. The funds will be used to enhance on-device processing capabilities, continue R&D in privacy-enhancing technologies, and expand engineering resources and its global footprint. “We have always believed that privacy and fraud prevention are not a tradeoff, but part of the same problem, solved together or not at all,” said Ricardo Amper, Founder and CEO of Incode. “Identiq is the piece that enhances our Privacy b
Gurobi Introduces New Optimization Game Set in a Fast-Paced Coffee Shop25.6.2026 15:00:00 CEST | Press release
Gurobean, companion to the “Burrito Optimization Game” with 85,000+ plays, introduces advanced concepts like nonlinearity and uncertainty. Gurobi Optimization, LLC, the leader in decision intelligence technology, today announced the launch of Gurobean: The Coffee Optimization Game, a new educational game that brings nonlinearity, simulation, and decision-making under uncertainty to life. Following the success of the Burrito Optimization Game—which has been played over 85,000 times by learners across the world since its launch in 2022—Gurobean places players behind the counter of a virtual coffee shop, where they must make critical decisions around pricing, staffing, queue management, inventory levels, and more. The free, interactive game furthers Gurobi’s ongoing commitment to open education, teaching players: The value of mathematical optimization How quickly real-world decision problems become too complex to solve by trial and error How nonlinearity and uncertainty make outcomes hard
In our pressroom you can read all our latest releases, find our press contacts, images, documents and other relevant information about us.
Visit our pressroom