LG-CHEM/TRANSTHERA
18.8.2020 01:02:10 CEST | Business Wire | Press release
LG Chem Life Sciences (“LG Chem”), a division of LG Chem, and TransThera Biosciences Co. Ltd. (“TransThera”), a clinical-stage biotechnology company based in Nanjing, China, announced today that LG Chem has entered an exclusive license agreement with TransThera, for the development and commercialization of TransThera’s TT-01025, a highly selective oral small molecule inhibitor of Semicarbazide-Sensitive Amine Oxidase/Vascular Adhesion Protein-1 (SSAO/VAP-1) that has shown promising efficacy in pre-clinical investigation in non-alcoholic steatohepatitis (NASH). TT-01025 is expected to enter Phase I trial in early 2021 in the US.
This press release features multimedia. View the full release here: https://www.businesswire.com/news/home/20200817005331/en/
NASH is a chronic and progressive liver disease characterized by fat accumulation and inflammation in the liver, which can lead to fibrosis and impaired liver function. The disease can be silent for a long period of time, but once it accelerates, severe damage and liver cirrhosis can occur, which can significantly impact liver function or can even result in liver failure or liver cancer. There are as yet no globally approved drugs for the indication. The inhibition of SSAO/VAP-1 blocks oxidative conversion and leucocyte transmigration during inflammation processes and exhibits therapeutic potential across a range of chronic inflammatory conditions, including NASH.
Under the terms of the agreement, LG Chem will obtain exclusive worldwide rights, except Greater China region and Japan, to develop and commercialize TT-01025. TransThera will receive upfront payment as well as development and sales milestone payments, totaling up to $350M, plus tiered royalties on the annual net sales. LG Chem will be responsible for the further development, manufacturing and commercialization of TT-01025.
“Leveraging TransThera’s expertise in drug discovery and LG Chem Life Science’s capability in drug development, we are excited to expand our portfolio in NASH and other metabolic disorders,” said Dr. Jeewoong Son, President of LG Chem Life Sciences. “TT-01025 has a mechanism of action potentially synergistic with those in our own pipeline, making a perfect fit for our strategy to tackle the complex pathophysiology of NASH.”
Dr. Frank Wu, Chairman and CEO of TransThera, commented, “Open innovation is an important part of TransThera’s R&D strategy. We are very excited to collaborate with LG Chem, with its strong and broad expertise and capabilities, to expedite the global development of TT-01025. TT-01025 is a novel, highly differentiated VAP-1 inhibitor, with attributes of minimum CNS exposure and high selectivity, rendering its low risk of drug interactions. We look forward to working with LG Chem to deliver a potential innovative drug for the treatment of NASH patients.”
About LG Chem Life Sciences
LG Chem Life Sciences is a business division within LG Chem, engaged in the development, manufacturing, as well as commercializing pharmaceutical products globally. LG Chem Life Sciences seeks to expand and make global presence by focusing on key core therapeutic areas of Immunology, Oncology, and Metabolic Diseases (specifically, diabetes and related metabolic diseases). To achieve such, its strategy is to actively pursue global collaboration encompassing from asset-centric to strategic investment and collaboration.
About TransThera Biosciences
TransThera Biosciences is a clinical-stage biotechnology company dedicated to developing innovative therapeutics to target diseases with major unmet medical needs via internal research platform and open innovation. TransThera's current portfolio covers therapeutic areas such as oncology, cardiovascular, and inflammatory diseases. For more information, please visit www.transtherabio.com
.
View source version on businesswire.com: https://www.businesswire.com/news/home/20200817005331/en/
Link:
About Business Wire
Subscribe to releases from Business Wire
Subscribe to all the latest releases from Business Wire by registering your e-mail address below. You can unsubscribe at any time.
Latest releases from Business Wire
Tecnotree Recognized in Two Gartner® Hype Cycle™ Reports for CSP Algorithmic Pricing28.7.2026 14:46:00 CEST | Press release
Tecnotree, a global digital platform and services leader for AI, 5G, and cloud-native technologies, today announced that it has been recognized in the CSP Algorithmic Pricing use case in the Gartner Hype Cycle for Emerging Technologies in the Communications Industry, 2026 report and in the CSP Algorithmic Pricing, CSP Digital Marketplaces and AI for CSP Customer Interactions use case in the Hype Cycle for Telco Cloud Services, 2026. This press release features multimedia. View the full release here: https://www.businesswire.com/news/home/20260728836223/en/ Tecnotree Recognized in Two Gartner® Hype Cycle™ Reports for CSP Algorithmic Pricing Communications service providers are under pressure from intensifying competition, tightening margins, and finite network capacity, while customer expectations for personalized, responsive pricing keep rising. Algorithmic pricing answers that pressure by replacing static monthly plans with real-time, network-aware monetization — pricing that moves wi
Klarna to Power Apple Upgrade, a New Hardware Leasing Program Offered by Apple28.7.2026 14:15:00 CEST | Press release
Klarna, the global digital bank and flexible payments provider, today announced it would be the leasing provider behind the Apple Upgrade program, a new hardware leasing option available from Apple in the United States. Lease Apple hardware for low monthly payments Provided by Klarna, Apple Upgrade offers customers a new way to pay for eligible iPhone, Mac, iPad and Apple Watch. Customers can select from 12- and 24-month leasing options for iPhone and Apple Watch, and 24- and 36-month leasing options for Mac and iPad. In addition, when customers first enroll in Apple Upgrade, they can trade in an existing device to further lower their monthly payments during their initial lease term. The freedom to upgrade, return, or buy When the lease ends, customers choose what suits them: upgrade to the latest model1, purchase their device, or return it. A seamless checkout, and easy to manage payments Apple and Klarna have built an easy and seamless checkout experience which shows customers exactl
Third-Party EPDs Confirm C-Crete Cement Cuts Embodied Carbon by up to 95% — and It’s Already Being Poured Commercially28.7.2026 14:05:00 CEST | Press release
Two independently verified Environmental Product Declarations confirm cradle-to-gate carbon as low as 43.1 kg CO2-eq per metric ton. C-Crete’s platform technology turns a wide range of local rocks and industrial by-products into clinker-free cementitious binder — already in commercial use and adaptable to cement standards worldwide. C-Crete Technologies has published two Environmental Product Declarations (EPDs) verifying that its cements cut embodied carbon by up to 95% versus conventional portland cement. C-Crete’s technology converts a broad range of natural rocks and industrial by-products into cementitious binders with no clinker and no kiln, so production is inherently decentralized — and it is already being poured in commercial concrete today. This press release features multimedia. View the full release here: https://www.businesswire.com/news/home/20260728132467/en/ Representative C-Crete's project portfolio. More than 4000 tons of C-Crete's ultra-low carbon concrete have been
ExaGrid Releases Version 8.128.7.2026 14:00:00 CEST | Press release
Latest update includes support of Cohesity DataProtect, share quotas for MSPs, and NFS encryption over the wire ExaGrid®, the world’s largest independent backup storage vendor providing Tiered Backup Storage with the most comprehensive security and AI-Powered Retention Time-Lock for Ransomware Recovery, today announced the release of ExaGrid software version 8.1. The latest version includes: Support for Cohesity DataProtect Uses S3 protocol. Supports Cohesity Cloud Archive Direct. ExaGrid further deduplicates Cohesity deduplicated data, cutting the storage footprint in half. ExaGrid works with Cohesity NetBackup for mixed NetBackup and DataProtect environments. NFS encrypted over the wire Available for backup apps that support NFS encryption over the wire. ExaGrid already supports encryption over the wire with other protocols such as the Veeam Data Mover, CIFS, and S3. Share Quota ExaGrid already tracks how much data is going into each share. Now, a Managed Service Provider (MSP) can s
Omilia Appoints David Ogden as VP of Revenue Operations28.7.2026 14:00:00 CEST | Press release
Enterprise SaaS revenue operations leader joins Omilia to build the operational backbone for its next phase of global growth Omilia, a global leader in Self-Learning Agentic CX, today announced the appointment of Dave Ogden as Vice President of Revenue Operations. Ogden will be responsible for scaling Omilia’s global revenue operations function spanning sales operations, forecasting, and commercial execution as the company accelerates growth across its key markets. In this role, Ogden will design and operate the revenue infrastructure that connects sales, marketing, and customer success, including forecasting, pipeline management, and deal desk operations. He joins as Omilia expands its direct and partner-led go-to-market across the US, Europe, Latin America and Australia, and will play a central role in ensuring that growth scales in a disciplined, data-driven way. Ogden brings more than 15 years of enterprise SaaS revenue and commercial operations experience. He spent nine years at F
In our pressroom you can read all our latest releases, find our press contacts, images, documents and other relevant information about us.
Visit our pressroom