LAUSANNE-UNIVERSITY-HOSP
31.5.2016 13:01:09 CEST | Business Wire | Press release
A study, published yesterday in Nature Medicine , has shown that T follicular helper (Tfh) cells serve as the dominant cell reservoir for HIV infection. The study was led by Professors Matthieu Perreau and Giuseppe Pantaleo from the Service of Immunology and Allergy, Lausanne University Hospital, Lausanne, Switzerland.
The researchers have investigated the HIV reservoir in aviremic individuals treated for several years (up to 14 years) with antiretroviral (ART) therapy. The study demonstrates that a population of CD4 T cells residing within the germinal centers of lymph nodes, known as Tfh cells, serves as the dominant cell reservoir for HIV infection. The Tfh cells which represent less than 1% of total CD4 T cells in long-term ART treated individuals, contained replication competent and infectious virus. Germinal centers are difficult to access to cytotoxic CD8 T cells and thus represent a privileged anatomic site, e.g. a sanctuary, for the persistence of HIV in Tfh cells in long-term ART treated individuals.
Despite the major advances in ART therapy and the effective suppression of HIV replication, ART is not capable of eliminating HIV. HIV invariably rebounds after ART interruption and therefore life-time ART therapy is currently required for controlling virus replication. The present study appeared in Nature Medicine shed light on a fundamental issue, i.e. the identification of the cells that may be responsible for the rapid rebound of virus replication following ART interruption.
“The identification of Tfh cells as the major cell compartment containing replication competent and infectious HIV represents a major advance in our understanding of the mechanisms of HIV persistence following many years of ART-mediated virus suppression”, says Prof. Matthieu Perreau.
“We are very excited of the identification of Tfh cells as the major cell reservoir for HIV in long-term treated individuals. These observations will promote the development of therapeutic immune-based interventions that can directly target the HIV cell reservoir and have substantial impact in accelerating research in the fields of HIV functional cure and eradication”, says Prof. Pantaleo.
View source version on businesswire.com: http://www.businesswire.com/news/home/20160531005501/en/
Contact:
Lausanne University Hospital
Prof. Giuseppe Pantaleo
Giuseppe.Pantaleo@chuv.ch
or
Matthieu
Perreau
Matthieu.Perreau@chuv.ch
About Business Wire
Subscribe to releases from Business Wire
Subscribe to all the latest releases from Business Wire by registering your e-mail address below. You can unsubscribe at any time.
Latest releases from Business Wire
Lyft App Launches in Europe30.9.2026 14:00:00 CEST | Press release
North American riders can use their Lyft app when traveling in Europe Key takeaways: North American Lyft riders can now use one app in the U.S., Canada, and Europe. No need to download anything new. New technology allows the Lyft app to integrate any third-party marketplace, laying the groundwork for future international growth. Lyft has transformed from an everyday rideshare company into a global, multi-mobility platform. Starting today, Lyft (NASDAQ: LYFT) riders can use their Lyft app in cities across Europe. Early access to the Lyft app rolls out in Barcelona and Hamburg first; throughout October, the Lyft app will become available for riders to use in some of Europe’s largest cities including London, Rome, Paris, Berlin, Athens, and Warsaw. By the end of October riders visiting Spain, Italy, Greece, Poland, England, Scotland, Ireland, Austria, France, and Germany will have one go-to app when they cross the Atlantic, building on the foundations from this past summer beta testing th
A Workplace Worth Toasting: Bacardi Continues its Rise on Forbes World’s Best Employers List30.9.2026 13:45:00 CEST | Press release
Bacardi Takes Top Spot Among Spirits Companies with Jump to #69 Bacardi Limited is proving that a workplace worth toasting keeps getting better. The family-owned business has once again been named to the Forbes World's Best Employers list, taking the top spot among spirits companies. Climbing 17 places since last year, in 2026 Bacardi comes in at #69 globally. The jump in ranking reflects a commitment to creating a workplace where employees feel valued, empowered, and inspired to grow while helping shape the future of the company. This press release features multimedia. View the full release here: https://www.businesswire.com/news/home/20260930327935/en/ Bacardi Limited Leads Spirits Companies Forbes World's Best Employers 2026 Ranking. “At Bacardi, great moments start with great people. That's why we listen carefully to what they're telling us, learn from that feedback, and keep evolving. We want people to feel clear on how they can grow, confident they can make their mark, and suppor
Forrester’s 2027 European Predictions: Despite A Strong Desire To Regain Its Digital Sovereignty, Europe Will Selectively Reset, Not Sever, Key Technology Relationships30.9.2026 13:33:00 CEST | Press release
New AI sovereignty and platform governance rules will signal strategic intent but deliver limited near-term impact According to Forrester’s (Nasdaq: FORR) 2027 European predictions, unveiled today at Forrester’s Technology & Innovation Forum EMEA, Europe will enter 2027 determined to recover its digital autonomy, but the gap between its ambition and control will widen. More than half of European companies embracing AI will reduce their dependence on US hyperscalers due to sovereignty concerns, moving their critical data and applications to European providers. A lack of end-to-end sovereign alternatives, however, will require consumers, companies, and policymakers to pursue selective digital autonomy, which consequently will reshape consumer behaviours, cloud choices, mobility, resilience, and trade strategy with China. Forrester’s Predictions reports offer forward-looking insights into trends to help executives and their teams anticipate change, reduce uncertainty, and make confident d
Vasion® Named a Leader in the 2026 IDC MarketScape for Worldwide Print Management Solutions as Enterprise Print Becomes AI Ready30.9.2026 13:30:00 CEST | Press release
Vasion, the intelligent print automation company, today announced it has been named a Leader in the IDC MarketScape for Worldwide Print Management Solutions 2026 Vendor Assessment (doc # US54124826, September 2026). This press release features multimedia. View the full release here: https://www.businesswire.com/news/home/20260930788016/en/ According to the IDC MarketScape, "Organizations in sectors such as education, healthcare, government, manufacturing, financial services, and retail should consider Vasion when seeking support for business process automation revolving around print, output, and agentic or rules-based workflows. Vasion customers may derive considerable value from the vendor's solutions in support of unifying their organizations' digital transformation efforts, particularly where a single portal with functionality extending beyond print management is sought, and especially where FedRAMP® High Authorization, a SOC 2 Type II report, or ISO 27001/42001 certification is req
Pantheon Expands Middle East Presence With New Abu Dhabi Office and Senior Regional Appointment30.9.2026 12:56:00 CEST | Press release
Abu Dhabi office, based in ADGM, continues Pantheon’s global expansion to serve growing client demand in key markets such as the Middle EastFiras Mallah joins as Managing Director and Head of Middle East to lead capital formation with sovereign wealth funds, family offices, and financial institutions across the region Pantheon, a leading global private markets firm with approximately $84bn in assets under management, today announced the expansion of its presence in the Middle East with the opening of its first office in ADGM, the international financial center based in Abu Dhabi, alongside the appointment of Firas Mallah as Managing Director and Head of Middle East. Demand for access to private equity, infrastructure, and private credit strategies continues to build among sophisticated investors across the Middle East, who recognize Pantheon for its 40-year track record of innovation and expertise across primaries, secondaries and co-investment opportunities. Secondaries – pioneered by
In our pressroom you can read all our latest releases, find our press contacts, images, documents and other relevant information about us.
Visit our pressroom