Lausanne University Hospital (CHUV): T Follicular Helper Cells – A Key to the Understanding of the Mechanisms of HIV Persistence
A study, published yesterday in Nature Medicine , has shown that T follicular helper (Tfh) cells serve as the dominant cell reservoir for HIV infection. The study was led by Professors Matthieu Perreau and Giuseppe Pantaleo from the Service of Immunology and Allergy, Lausanne University Hospital, Lausanne, Switzerland.
The researchers have investigated the HIV reservoir in aviremic individuals treated for several years (up to 14 years) with antiretroviral (ART) therapy. The study demonstrates that a population of CD4 T cells residing within the germinal centers of lymph nodes, known as Tfh cells, serves as the dominant cell reservoir for HIV infection. The Tfh cells which represent less than 1% of total CD4 T cells in long-term ART treated individuals, contained replication competent and infectious virus. Germinal centers are difficult to access to cytotoxic CD8 T cells and thus represent a privileged anatomic site, e.g. a sanctuary, for the persistence of HIV in Tfh cells in long-term ART treated individuals.
Despite the major advances in ART therapy and the effective suppression of HIV replication, ART is not capable of eliminating HIV. HIV invariably rebounds after ART interruption and therefore life-time ART therapy is currently required for controlling virus replication. The present study appeared in Nature Medicine shed light on a fundamental issue, i.e. the identification of the cells that may be responsible for the rapid rebound of virus replication following ART interruption.
“The identification of Tfh cells as the major cell compartment containing replication competent and infectious HIV represents a major advance in our understanding of the mechanisms of HIV persistence following many years of ART-mediated virus suppression”, says Prof. Matthieu Perreau.
“We are very excited of the identification of Tfh cells as the major cell reservoir for HIV in long-term treated individuals. These observations will promote the development of therapeutic immune-based interventions that can directly target the HIV cell reservoir and have substantial impact in accelerating research in the fields of HIV functional cure and eradication”, says Prof. Pantaleo.
Information om Business Wire
101 California Street, 20th Floor
CA 94111 San Francisco
Følg pressemeddelelser fra Business Wire
Skriv dig op her og modtag pressemeddelelser på mail. Indtast din mail, klik på abonner og følg instruktionerne i den udsendte mail.
Flere pressemeddelelser fra Business Wire
GE-RENEWABLE-ENERGY24.9.2018 09:02 | pressemeddelelse
GE Renewable Energy Launches Cypress Onshore Wind Platform, Designed to Grow, Adapt, Thrive and Lower the Cost of Electricity for Customers
MA-MARKETSIGHT24.9.2018 08:32 | pressemeddelelse
MarketSight Now Available in Six Languages
CYTOX24.9.2018 07:02 | pressemeddelelse
Cytox Expands Collaboration with AIBL to Identify Those Most at Risk to Rapidly Progress to Alzheimer’s
FL-MLB22.9.2018 00:15 | pressemeddelelse
American Airlines Announces Nonstop Philadelphia (PHL) to Orlando Melbourne (MLB)
NY-BCW/PALLADINO21.9.2018 19:45 | pressemeddelelse
Amy Palladino Joins BCW as Executive Vice President, Managing Director, Corporate Practice
HEIDELBERG-ENGINEERING21.9.2018 18:43 | pressemeddelelse
Heidelberg Engineering Announces the CE-Marking of ANTERION
I vores nyhedsrum kan du læse alle vores pressemeddelelser, tilgå materiale i form af billeder og dokumenter, og finde vores kontaktoplysninger.Besøg vores nyhedsrum