Lausanne University Hospital (CHUV): T Follicular Helper Cells – A Key to the Understanding of the Mechanisms of HIV Persistence
A study, published yesterday in Nature Medicine , has shown that T follicular helper (Tfh) cells serve as the dominant cell reservoir for HIV infection. The study was led by Professors Matthieu Perreau and Giuseppe Pantaleo from the Service of Immunology and Allergy, Lausanne University Hospital, Lausanne, Switzerland.
The researchers have investigated the HIV reservoir in aviremic individuals treated for several years (up to 14 years) with antiretroviral (ART) therapy. The study demonstrates that a population of CD4 T cells residing within the germinal centers of lymph nodes, known as Tfh cells, serves as the dominant cell reservoir for HIV infection. The Tfh cells which represent less than 1% of total CD4 T cells in long-term ART treated individuals, contained replication competent and infectious virus. Germinal centers are difficult to access to cytotoxic CD8 T cells and thus represent a privileged anatomic site, e.g. a sanctuary, for the persistence of HIV in Tfh cells in long-term ART treated individuals.
Despite the major advances in ART therapy and the effective suppression of HIV replication, ART is not capable of eliminating HIV. HIV invariably rebounds after ART interruption and therefore life-time ART therapy is currently required for controlling virus replication. The present study appeared in Nature Medicine shed light on a fundamental issue, i.e. the identification of the cells that may be responsible for the rapid rebound of virus replication following ART interruption.
“The identification of Tfh cells as the major cell compartment containing replication competent and infectious HIV represents a major advance in our understanding of the mechanisms of HIV persistence following many years of ART-mediated virus suppression”, says Prof. Matthieu Perreau.
“We are very excited of the identification of Tfh cells as the major cell reservoir for HIV in long-term treated individuals. These observations will promote the development of therapeutic immune-based interventions that can directly target the HIV cell reservoir and have substantial impact in accelerating research in the fields of HIV functional cure and eradication”, says Prof. Pantaleo.
Information om Business Wire
101 California Street, 20th Floor
CA 94111 San Francisco
Følg pressemeddelelser fra Business Wire
Skriv dig op her og modtag pressemeddelelser på mail. Indtast din mail, klik på abonner og følg instruktionerne i den udsendte mail.
Flere pressemeddelelser fra Business Wire
ANT-FINANCIAL20.6.2018 03:12 | pressemeddelelse
Ant Financial to Share Full Suite of AI Capabilities with Asset Management Companies
WA-AVALARA-INC19.6.2018 23:22 | pressemeddelelse
Avalara Announces Closing of Initial Public Offering and Full Exercise of the Underwriters’ Option to Purchase Additional Shares
UNILEVER19.6.2018 19:44 | pressemeddelelse
Unilever Calls on Content Creators and Distributors to Eradicate Stereotypes
AZ-UNIVERSAL-LASER19.6.2018 14:07 | pressemeddelelse
Universal Laser Systems Expands Its Materials Database with Henkel, Hexcel and Saint-Gobain Materials
NY-VALENCE-GROUP19.6.2018 13:59 | pressemeddelelse
Valence Advises Itaúsa on Sale of Brazilian Chemical Co Elekeiroz to H.I.G. Capital
CA-DOLE-FOOD-COMPANY19.6.2018 12:02 | pressemeddelelse
Dole Adds Industry Veteran Michael Solomon as President of Dole Fresh Vegetables
I vores nyhedsrum kan du læse alle vores pressemeddelelser, tilgå materiale i form af billeder og dokumenter, og finde vores kontaktoplysninger.Besøg vores nyhedsrum