INVERSAGO-PHARMA
19.5.2022 14:02:09 CEST | Business Wire | Press release
Inversago Pharma Inc. (“Inversago”), a clinical stage biotech company with a unique portfolio of CB1 inverse agonists, announces the presentation of preclinical data at the 59th Congress of the European Renal Association (ERA), the largest annual nephrology meeting in Europe, currently held in Paris, France.
These data show that INV-202, the company’s lead peripheral CB1 blocker, reduced renal injury in a murine model of Streptozotocin (STZ)-induced Diabetes. More specifically, INV-202 reduced glomerular injury, renal fibrosis and injury to proximal tubular epithelial cells, and also preserved podocyte structure and function. In particular, there was a marked, dose-dependent reduction in albuminuria in this model of diabetes and associated kidney injury.
“The study showed that treatment with INV-202 reduced the progression of nephropathy in STZ-induced diabetic mice. Improvements in kidney size, function, and renal matrix remodeling, with corresponding gene expression were noted with both doses of 0.3 mg/kg and 3 mg/kg of INV-202”, said Dr. Tony Jourdan, Research Lead at the National Institute of Health and Medical Research (Inserm) U1231 Lipids, Nutrition, Cancer Research Centre, in Dijon, France.
Dr. Glenn Crater, CMO at Inversago added: “These results may hold promise for those patients with diabetic kidney disease for whom such a potential therapy could further slow and delay the occurrence of end-stage renal disease.”
Based on these supportive preclinical results, along with encouraging Phase 1 results, Inversago is looking forward to launching Phase 2 clinical development for INV-202.
About INV-202
INV-202 is a small molecule CB1 inverse agonist / antagonist being developed by Inversago for the potential treatment of several metabolic conditions, including Diabetic Nephropathy. It is specifically designed to preferentially interact with peripheral CB1 receptors located in the kidneys, gastro-intestinal tract, liver, pancreas, adipose tissues, muscles, lungs and other organs, thus aiming at a safe and effective therapeutic approach without the known liabilities of centrally-acting CB1 blockers. The peripheral CB1 blockade is a well-documented pathway, linked to many clinically meaningful metabolic benefits.
About STZ Model
In this treatment model of diabetic kidney disease, mice were allowed to develop complication of diabetes for twelve weeks after STZ injection. Then these C57BL6/J mice (8 per treatment group) were randomized to receive a daily oral dose of INV-202, 0.3 mg/kg and 3 mg/kg, or vehicle for four weeks. Five mice not treated with STZ were used as a non-diabetic control. At the end of treatment, urinary albumin to creatinine ratio (ACR), renal matrix remodeling, glomerular filtration and interstitial fibrosis were assessed in addition to glucose levels, body weight, and organ weights.
About Diabetic Nephropathy
Diabetic nephropathy (DN) occurs when diabetes causes damage to the glomeruli and proximal renal tubules that are essential to blood filtering and waste elimination. As a complication of type 1 and type 2 diabetes, diabetic nephropathy affects approximately 1 in 3 people living with diabetes in the United States. No cure exists for this indication and available medications only help slowing the progression of the disease and control related complications. Inversago believes that the development of a peripheral CB1 blockade represents a promising therapeutic avenue for such a metabolic disorder.
About Inversago Pharma
Located in Montreal, Inversago Pharma is a privately owned Canadian biotech company at clinical stage, specialized in the development of new therapies focusing on CB1 blockade, based on first-in-class, peripherally acting CB1 inverse agonists. Inversago aims to provide new treatment options that improve the lives of patients affected by metabolic conditions such as Diabetic Nephropathy (DN), Non-Alcoholic Steatohepatitis (NASH), complications from obesity, Hypertriglyceridemia (HTG), Type 1 Diabetes (T1D) and Prader-Willi Syndrome (PWS), as well as fibrotic indications like Progressive Fibrosis-Interstitial Lung Disease (PF-ILD), including Idiopathic Pulmonary Fibrosis (IPF). For more information, visit inversago.com
.
View source version on businesswire.com: https://www.businesswire.com/news/home/20220519005226/en/
Link:
About Business Wire
Subscribe to releases from Business Wire
Subscribe to all the latest releases from Business Wire by registering your e-mail address below. You can unsubscribe at any time.
Latest releases from Business Wire
International Optics and Photonics Community Invited to SPIE Photonics West 202714.10.2026 16:01:00 CEST | Press release
Thousands from around the globe will share research breakthroughs and industry innovations in optics and photonics SPIE, the international society for optics and photonics, invites the global optics and photonics community to register for SPIE Photonics West 2027, happening 30 January–4 February at the Moscone Center in San Francisco, California. The dynamic week draws 24,000 researchers, engineers, students, and business leaders from around the globe, providing technical presentations, exhibitions, and networking opportunities that fuel collaboration and real-world innovation. This press release features multimedia. View the full release here: https://www.businesswire.com/news/home/20261013654749/en/ SPIE Photonics West will be held 30 January-4 February 2027 in San Francisco, California. The annual event brings together 24,000 people from the global optics and photonics community to foster collaboration and innovation. SPIE anticipates more than 4,500 presentations will be given acro
Toluna Appoints Amy Fenton as Chief Executive Officer14.10.2026 15:30:00 CEST | Press release
Appointment completes the planned succession announced on October 8, 2026. Founder Frédéric Charles Petit continues as Board member, Senior Advisor and Shareholder. Toluna, a global leader in consumer insights and market research technology, today announces the appointment of Amy Fenton as Chief Executive Officer, effective October 15, 2026. Ms. Fenton succeeds Frédéric Charles Petit, who founded Toluna and has led the company for 25 years. This press release features multimedia. View the full release here: https://www.businesswire.com/news/home/20261014103169/en/ Amy Fenton appointed as new Chief Executive Officer, Toluna The appointment concludes the structured succession process announced on October 8, 2026, led by the Board in close consultation with Mr. Petit and supported by a leading executive search firm. Ms. Fenton brings more than 30 years of leadership experience in the insights and analytics industry. She joins Toluna from MarketCast, where she served as Chief Executive Off
BanyanGlobal Family Business Advisors Named Family Business Advisory Practice of the Year at the STEP Private Client Awards for the Fourth Time14.10.2026 15:05:00 CEST | Press release
The international recognition, also awarded to the firm in 2018, 2020 and 2021, honors Banyan's approach of pairing governance with the skills and confidence families need for long-term ownership BanyanGlobal Family Business Advisors ("Banyan") has been named Family Business Advisory Practice of the Year at the 21st annual STEP Private Client Awards, one of the most respected international honors in the private client profession. It is the fourth time Banyan has won the category, following wins in 2018, 2020 and 2021. This press release features multimedia. View the full release here: https://www.businesswire.com/news/home/20261013883351/en/ Kelly Greig, STEP Board Member and Dennis Jaffe, BanyanGlobal Family Business Advisors at the awards ceremony. BanyanGlobal won the Family Business Advisory Practice of the Year at the 21st Annual STEP Private Client Awards. The independent judging panel singled out Banyan's approach: "BanyanGlobal Family Business Advisors has redefined family busi
Telekom Srbija Group Expands AI Investment and Strengthens U.S. Technology Partnerships14.10.2026 15:02:00 CEST | Press release
Leading Southeast European Telecommunications and Technology Group Advances AI Innovation Through International Collaboration, Startup Investments and 5G Infrastructure. Following the October 1 agreement between Serbia and the United States to strengthen cooperation in artificial intelligence (AI), Telekom Srbija Group is expanding its AI investment and deepening relationships with leading U.S. technology companies as part of its strategy to develop the next generation digital services. As part of these efforts, Telekom Srbija Group has engaged with the U.S. State Department, Department of Commerce and Export-Import Bank to explore opportunities for technology cooperation and project financing, with the ambition of becoming a preferred regional partner for U.S. companies. “Artificial intelligence represents one of the greatest opportunities for the future of telecommunications and digital services,” said Vladimir Lučić, CEO of Telekom Srbija Group. “We have been investing in this techn
Lenovo Uncovers What Happens When Entrepreneurs Look Beyond Borders for Support14.10.2026 15:00:00 CEST | Press release
New documentary series follows small business founders from around the world as unexpected connections and technology spark fresh ideas, new approaches to business challenges and opportunities for growth Today, Lenovo debuts the first episode of its new documentary series from Backing Every Business, its global initiative designed to connect small businesses with the people, technology and support they need to grow and thrive. The series features five businesses participating in Twinning, Lenovo’sprogram that brings small business founders from around the world together, connecting them through mentorship across shared growth goals, access to resources including technology, AI training, funding designed to help address real business challenges and turn new ideas into action. This press release features multimedia. View the full release here: https://www.businesswire.com/news/home/20261014736241/en/ The four-part series follows entrepreneurs from Japan, Mexico, the U.K. and the U.S. as
In our pressroom you can read all our latest releases, find our press contacts, images, documents and other relevant information about us.
Visit our pressroom