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Nichi GLOW: Japanese Beta-Glucan, in Children With Autism Spectrum Disorder, Improves Behavior, Sleep, and Gut Microbiome in a Clinical Study

In the first such report, children with Autism spectrum disorder (ASD) showed improvement in behaviour, learning skills and sleep, after oral consumption of AFO-202 strain of black yeast Aureobasidium Pullulans produced Beta 1,3 -1,6 glucan (Nichi GLOW), published in BMJ Neurology Open (http://dx.doi.org/10.1136/bmjno-2021-000203 ). Beneficial reconstitution of gut microbiota was also reported with Nichi GLOW, which is unique from other beta glucans by its source, production method, and purity.

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Autism is a neurodevelopmental disorder affecting 1 in 44 children in the developed world, with multiple causes and varying severity of manifestation. These children are more likely to develop neurodegenerative diseases in later life. In the study, Nichi GLOW intake improved CARS score and communication skills (https://www.youtube.com/watch?v=reJOjBMKSg4 ). Nichi GLOW controlled enterobacteria, a gut microbiome producing harmful proteins like curli and amyloid, leading to Alpha-synuclein misfolding and aggregation in the neurons, a cause of the disease (https://doi.org/10.1101/2021.10.26.21265505 ). Synucleinopathy spreading through gut-brain-axis to the brain, might cause Parkinson’s or Dementia, therefore, it’s worth studying the prophylaxis of Nichi Glucan range of products in neurodegenerative conditions, as microglia activation is one of the mechanisms of their action in brain (https://doi.org/10.1016/j.jns.2021.117554 ), says Dr. Raghavan, the principal investigator.

The findings were presented in a webinar commemorating Autism Sunday (https://www.ncrmniche.org/autismsunday2022/proceedings/index.html ), organized by Jesuit Antonyraj memorial Inter-disciplinary Center for Advanced Recovery and Education (JAICARE). Research conducted in Japan unraveled the hidden potentials (https://doi.org/10.1101/2021.08.05.21261640 ), of this ß-glucan; thanks to a wholesome ecosystem in Japan aiding development of novel solutions, which together with the trans-world inter-disciplinary network of healthcare expertise of GN Corp have made this path-breaking feat possible, commented the scientists. https://sponsored.bloomberg.com/article/jco/japan-where-high-tech-meets-high-value-foreign-direct-investment

Nichi Glucan range of products were approved as food additives in Japan in 1996 and don’t contain any commonly notified allergens. They are unique, being produced as an exo-polysaccharide by novel strains of Aureobasidium Pullulans in a GMP certified facility in Japan and exported in different brands: Nichi-GLOW, Neu-REFIX, Nichi Glucan & Nichi Glucan-REFIX ; not intended to diagnose, treat, cure, or prevent any disease & approval status may vary between countries. Publications are meant for academic and research initiative purposes; not to be construed as medical advice. Physicians’ advice is recommended for specific health queries.

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