CORCYM
CORCYM, the new, independent, medical device company dedicated to providing patients and cardiac surgeons with the best solutions to fight structural heart disease, announces today the enrollment of the first patient in the MANTRA study. MANTRA (M itral, A ortic aN d T ricuspid post-maR ket S tudy in a reA l-world setting) is a prospective, multi-arm, multi-center, global, post-market clinical follow-up study that monitors the safety and performance of the complete CORCYM portfolio in a real-world setting.
“The MANTRA study has been designed leveraging the umbrella study concept, as it contains a master protocol with endpoints applicable across the treatment options together with additional sub-studies for specific devices and dedicated endpoints. MANTRA currently contains three sub-studies: an aortic study, a mitral and tricuspid study, and a third study fully dedicated to the Memo 4D annuloplasty ring,” explained Prof. Bart Meuris (University Hospital Leuven, Belgium) Coordinating Investigator of the MANTRA aortic sub-study and part of the MANTRA Steering Committee together with Prof. Serdar Günaydın (Ankara City Hospital, Turkey), Prof. Jörg Kempfert (Deutsches Herzzentrum Berlin, Germany) and Prof. Patrizio Lancellotti (University Hospital Liège, CHU Sart Tilman, Belgium).
The first patient was implanted in Italy, at Città di Lecce Hospital with a Bicarbon aortic mechanical valve, which has been CE mark approved for use with low-dose anticoagulant therapy in low-risk patients1 . Conducted worldwide, the MANTRA study is planned to enroll 1,750 patients in approximately 100 centers with follow-up to 10 years.
“We are glad to take part in the MANTRA study and to have started enrolling patients in its aortic sub-study. As a primary endpoint, we will verify the device success at 30 days as defined by the VARC guidelines2 . Study patients will be followed-up annually to 10 years to assess the device safety and performance, together with the patient quality of life,” reported Dr. Giuseppe Santarpino , Principal Investigator at Città di Lecce Hospital, Italy.
“The launch of the MANTRA study confirms CORCYM’s commitment to continuously generate new clinical evidence in collaboration with cardiac surgeons to help them treat patients better today and in the future,” commented Christian Mazzi , CORCYM CEO.
About CORCYM
CORCYM is a global, independent, medical device company entirely focused on state-of-the-art surgical solutions to fight structural heart disease. CORCYM has a presence in more than 100 countries with approximately 850 employees and ensures strong continuous support to patients, healthcare professionals and healthcare systems worldwide. For more information, please visit www.corcym.com
___________________________
References:
- INR range 1.5-2.5 in patients at low risk for thromboembolic events undergoing single mechanical aortic valve replacement, as demonstrated by Torella et al., Am Heart J; 160:171-8, 2010.
- VARC: Valve Academic Research Consortium (Généreux, et al. 2021 Eur Heart J, 42(19):1825-1857).
View source version on businesswire.com: https://www.businesswire.com/news/home/20210716005014/en/
Link:
About Business Wire
Subscribe to releases from Business Wire
Subscribe to all the latest releases from Business Wire by registering your e-mail address below. You can unsubscribe at any time.
Latest releases from Business Wire
Daikin Leverages DataXstream’s OMS+ to Take Customer Experience to New Heights2.12.2025 16:03:00 CET | Press release
SAP-native platform will empower Daikin to reduce complexity, elevate the in-store/online customer experience, and optimize order accuracy across all locations DataXstream LLC, an SAP® Endorsed App partner developing intelligent solutions for SAP sales and distribution, announced today that Daikin Comfort Technologies North America, Inc. (Daikin), a subsidiary of Daikin Industries Ltd. and leading HVAC manufacturer, has selected its OMS+ platform to deliver real-time point-of-sales capabilities, along with an intuitive, streamlined order management to transform Daikin’s in-store and online customer experience. Leveraging SAP solutions, Daikin and DataXstream are elevating the way customers engage with Daikin’s stores and brand by delivering unparalleled, consistent point-of-sale capabilities, along with real-time visibility of orders and inventory across all sales channels. “Customers want a consistent and responsive experience, regardless of where they place their order,“ said Tim Yat
Halo Infinite and Elysium Senior Concept Designer Ben Mauro Launches HUXLEY: The Oracle - Sci-Fi Prequel Debuts as #1 Amazon New Release2.12.2025 16:00:00 CET | Press release
Ben Mauro, the acclaimed concept artist and worldbuilder behind Halo Infinite, Call of Duty, Elysium, and The Predator, today announced the US release of HUXLEY: The Oracle. The book, serving as the narrative prequel to Mauro’s expanding HUXLEY universe, has already reached #1 in Amazon’s New Releases for Conceptual Art based on pre-orders alone. This press release features multimedia. View the full release here: https://www.businesswire.com/news/home/20251202609807/en/ HUXLEY: The Oracle Cover illustration HUXLEY: The Oracle departs from the graphic novel format in the first book, adopting an immersive narrative art book format that pairs cinematic, full-page illustrations alongside storytelling. Using a format familiar to readers of Simon Stålenhag’s Tales from the Loop, the book places world-building at the forefront, delivering a large-scale, atmospheric introduction to the world of HUXLEY that is fitting to the new story. HUXLEY: The Oracle unites a "dream team" of industry heavyw
Ullevaal Stadium Among the First in the World to Install FIFA Quality Pro Certified LED Lighting System2.12.2025 15:15:00 CET | Press release
A newly installed, state-of-the-art LED lighting system at Ullevaal Stadium has transformed the playing, viewing, and entertainment experience for athletes and spectators, and has made Norway’s national stadium one of the few in the world with FIFA Quality Pro Certification. This press release features multimedia. View the full release here: https://www.businesswire.com/news/home/20251201171907/en/ The state-of-the-art TLC for LED® lighting system at Ullevaal Stadium has made Norway’s national stadium one of the few in the world with FIFA Quality Pro Certification. Home to Norway’s national football team, Ullevaal Stadium opened in 1926 and has a rich history of hosting significant sporting and entertainment events. When stadium ownership at the Football Association of Norway (NFF) decided to upgrade the venue’s lighting, they envisioned a system with the most advanced LED technology for the best possible playing, viewing, and entertainment experience. “Our main priorities for the new
Logical Intelligence Achieves 76 Percent on Putnam Benchmark, Highlighting Shift Beyond Large Language Models to Language-free, Mathematically Grounded Models2.12.2025 15:15:00 CET | Press release
Over the last decade, artificial intelligence (AI) has been largely built around large language models (LLMs). These systems are based on a language and guess words in a chain in the form of tokens. As a result, they frequently hallucinate and require vast compute and power infrastructure to solve tasks. The moment systems like public safety, national infrastructure, and industrial automation need logic, LLMs break and introduce safety risks. Token-free language independent models represent a new direction for AI. They do not predict words. They search for correct solutions and require less compute. Logical Intelligence is the first company building exclusively around mathematically derived, non autoregressive EBM (Energy Based Model) reasoning. Today, Logical Intelligence announced that its Aleph tool achieved a 76 percent score on the Putnam Benchmark, one of the most demanding mathematical reasoning tests in artificial intelligence. The benchmark measures a model’s ability to solve
MUSASHI JAPAN Launches “Gift Campaign 2025” - A Holiday Tradition Honoring Craftsmanship Through Meaningful Gifts2.12.2025 15:07:00 CET | Press release
MUSASHI JAPAN by TAIMATSU announces the return of its year-end celebration, Gift Campaign 2025, a seasonal tradition that transforms holiday shopping into an experience of appreciation, craftsmanship, and cultural generosity. This press release features multimedia. View the full release here: https://www.businesswire.com/news/home/20251202812444/en/ Rather than focusing on discounts, MUSASHI embraces the philosophy that true value lies in tools that last and in the gestures that accompany them. This year’s campaign invites customers to discover gifts that enrich their craft in the kitchen, each thoughtfully chosen to support the longevity and performance of every Musashi blade. Inspired by the Japanese principle of omotenashi, the campaign offers customers tiered gifts based on their total purchase amount, ensuring that every contribution is met with gratitude and purpose. From December 2 to December 25, 2025, customers shopping in MUSASHI JAPAN stores will receive: Tier 1: Oil and Rus
In our pressroom you can read all our latest releases, find our press contacts, images, documents and other relevant information about us.
Visit our pressroom