AXON Presented at CTAD the Additional Results from the 18 Months Follow up of the Phase I Study
AXON Neuroscience presented the results of the 18 month follow-up study with an active tau vaccine at the 9th International Conference on Clinical Trials in Alzheimer’s Disease (CTAD) in San Diego (US). These results have confirmed in longer observation the encouraging phase I study results. The detailed phase I study results were published in The Lancet Neurology on December 9th 2016.
FOLLOW UP STUDY WITH THE AADVAC 1 VACCINE
The primary objective of the follow-up study was to assess the long-term safety and tolerability of AADvac1 and immunogenicity over a period of an additional 18 months. The patients received two additional AADvac1 booster vaccinations aiming to ensure persistence of induced therapeutic antibodies.
At CTAD, AXON’s Medical Director, Matej Ondrus, announced that the study confirmed overall excellent results of AADvac1 in a total treatment period of 24 months in patients with Alzheimer’s disease. Additionally, the study confirmed the ability of the booster vaccines to sustain the desired immune response. “While already in the Phase II study, AADvac1 is currently the most advanced tau disease modifying therapy in the field with the potential to be used also as a preventive treatment for AD”, said Matej Ondrus.
AADVAC1 TAU VACCINE
AADvac1 is an active tau vaccine against Alzheimer’s disease and related tauopathies. AADvac1 is designed to elicit antibodies against the pathological tau protein, which is the primary cause of neurofibrillary pathology in Alzheimer’s disease. These antibodies are expected to prevent the tau protein from pathological interactions, and thus to stop the progress of Alzheimer’s disease and neurodegeneration.
AXON Neuroscience is a clinical-stage biotech company developing disease-modifying therapeutics for Alzheimer's disease and other tauopathies. AXON is the first company which has successfully launched a Phase 2 study with a disease-modifying active immunotherapy against pathologically modified tau protein. The Phase 2 study is conducted in 8 European countries and has already recruited 44 out of 185 participating patients with mild AD.
+421 903 576 315
Information om Business Wire
101 California Street, 20th Floor
CA 94111 San Francisco
Følg pressemeddelelser fra Business Wire
Skrive dig op her og du vil løbende modtage pressemeddelelser på mail. Indtast din mail, klik på abonner og følg instruktionerne i den udsendte mail.
Flere pressemeddelelser fra Business Wire
ASTRAZENECA19.11.2017 00:02 | pressemeddelelse
New Data Show Benefit of Tagrisso in Patients with EGFR-mutated Non-small Cell Lung Cancer and Central Nervous System Metastases
ASTRAZENECA18.11.2017 19:22 | pressemeddelelse
New England Journal of Medicine Publishes Results of Phase III FLAURA Trial in the 1st-Line Treatment of EGFR-mutated Non-small Cell Lung Cancer
CHINA-HI-TECH-FAIR18.11.2017 10:13 | pressemeddelelse
Much-Anticipated CHTF 2017 Top 10 Products Are Unveiled
NY-MADISON-REALTY17.11.2017 17:22 | pressemeddelelse
Madison Realty Capital Provides $64.0 Million Construction Financing for 200 Kent Avenue Development in Williamsburg, Brooklyn
NCARDIA17.11.2017 13:33 | pressemeddelelse
Ncardia Announces Completion of €10.5M Investment Round
VOCALINK17.11.2017 10:37 | pressemeddelelse
Double Win for Vocalink at the 2017 Payments Awards
I vores nyhedsrum kan du læse alle vores pressemeddelelser, tilgå materiale i form af billeder og dokumenter, og finde vores kontaktoplysninger.Besøg vores nyhedsrum