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Agendia to Deliver Robust Suite of Data Advancing Breast Cancer Care at ASCO 2022

Agendia, Inc., a commercial stage company focused on enabling optimized decision-making by providing physicians with next-generation diagnostic and information solutions that can be used to help improve outcomes for breast cancer patients worldwide, today announced it will present new data from ongoing clinical research evaluating its comprehensive genomic tests at the upcoming American Society of Clinical Oncology Annual Meeting (ASCO), taking place June 3-7, 2022 in Chicago, Illinois.

Data will highlight Agendia’s clinical focus on whole transcriptome analysis as well as breast cancer care for underserved populations, in addition to several sub-studies derived from the company’s FLEX Registry, the real-world, multicenter, prospective, observational breast cancer study. Two abstracts selected by ASCO for oral discussion will feature an investigation of the ImPrint genomic test, currently for research use only, from the I-SPY trial series and an analysis from FLEX of hormone receptor-positive breast cancer in Black women classified by BluePrint® .

The company believes the FLEX Registry’s approach to cancer research is accelerating impactful data generation, aimed at redefining cancer care. Its patient-centric design and national network of participating sites is backed by Agendia’s infrastructure, allowing its investigator-initiated sub-studies to produce important results that have the potential to drive science forward, like those being shared at ASCO 2022.

Following are details of the nine Agendia abstracts that have been accepted for poster discussion or poster sessions at the ASCO 2022 Annual Meeting:

Poster discussion sessions

  • The ImPrint immune signature to identify patients with high-risk early breast cancer who may benefit from PD1 checkpoint inhibition in I-SPY2
    Authors: Kuilman, MM., et al.
    Presenter: Lorenza Mittempergher, PhD | Research and Development, Agendia NV
    Session: Breast Cancer – Local/Regional/Adjuvant
    Poster Discussion: Monday, June 6, 2022 | 1:15 PM-2:45 PM CDT
    Abstract #: 514
  • Whole transcriptomic analysis of HR+ breast cancer in Black women classified as basal-type by BluePrint
    Authors: Reid, S., et al.
    Presenter: Sonya A. Reid, MD, MPH | Vanderbilt University Medical Center
    Session: Breast Cancer – Local/Regional/Adjuvant
    Poster Discussion: Monday, June 6, 2022 | 1:15 PM-2:45 PM CDT
    Abstract #: 517
    Poster sessions
  • Whole transcriptome analysis of tumors with discordant oncotype and MammaPrint results in the FLEX trial
    Authors: Socoteanu, M., et al.
    Session: Breast Cancer – Local/Regional/Adjuvant
    Session Date & Time: Monday, June 6, 2022 | 8:00 AM-11:00 AM CDT
    Abstract #: 556
  • Clinical implications for patients with discordant oncotype and MammaPrint results
    Authors: Socoteanu, M., et al.
    Session: Breast Cancer – Local/Regional/Adjuvant
    Session Date & Time: Monday, June 6, 2022 | 8:00 AM-11:00 AM CDT
    Abstract #: 560
  • Investigation of a genomic signature for transcription factor MAF gene amplification and lack of bisphosphonate benefit in early breast cancer
    Authors: Nasrazadani, A., et al.
    Session: Breast Cancer – Local/Regional/Adjuvant
    Session Date & Time: Monday, June 6, 2022 | 8:00 AM-11:00 AM CDT
    Abstract #: 559
  • Identification of transcriptional changes with MammaPrint and BluePrint in early-stage breast cancer after neoadjuvant chemotherapy
    Authors: Chung, A., et al.
    Session: Breast Cancer – Local/Regional/Adjuvant
    Session Date & Time: Monday, June 6, 2022 | 8:00 AM-11:00 AM CDT
    Abstract #: 585
  • Distribution of breast cancer molecular subtypes within receptor classifications: Lessons from the I-SPY2 trial and FLEX Registry
    Authors: Cha, J., et al.
    Session: Breast Cancer – Local/Regional/Adjuvant
    Session Date & Time: Monday, June 6, 2022 | 8:00 AM-11:00 AM CDT
    Abstract #: 592
  • FLEX, the 30,000 breast cancer transcriptome project: A platform for early breast cancer research using full-genome arrays paired with clinical data
    Authors: Ma, C., et al.
    Session: TBC
    Session Date & Time: Monday, June 6, 2022 | 8:00 AM-11:00 AM CDT
    Abstract #: TPS612
  • Defining transcriptomic profiles of early-stage mucinous breast cancers: A FLEX sub study
    Authors: Sivapiragasam, A., et al.
    Session: Developmental Therapeutics – Molecularly Targeted Agents and Tumor Biology
    Session Date & Time: Sunday, June 5, 2022 | 8:00 AM-11:00 AM CDT
    Abstract #: 3134

Agendia will be sharing important updates on its Twitter , Facebook and LinkedIn pages throughout the conference. The event program can be found at the ASCO 2022 website.

About Agendia

Agendia is a mission-driven, commercial stage company focused on enabling optimized decision-making by providing physicians with next-generation diagnostic and information solutions that can be used to help improve outcomes for breast cancer patients worldwide. The company currently offers two commercially-available genomic profiling tests that help surgeons, oncologists and pathologists to personalize treatment for women at critical intervention points throughout their patient journey.

MammaPrint® is a 70-gene prognostic test that, along with other clinicopathologic factors, determines a specific patient’s breast cancer recurrence risk. BluePrint® is an 80-gene molecular subtyping test that identifies the underlying biology of an individual breast cancer to provide information about its behavior, long-term prognosis and potential response to systemic therapy. Together, MammaPrint® and BluePrint® provide a holistic view of the biology underlying an individual patient’s breast cancer, enabling physicians to objectively select the best treatment plan.

For more information on Agendia’s assays and ongoing trials, please visit www.agendia.com .

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