CA-AGENDIA
10.12.2021 00:02:04 CET | Business Wire | Press release
Agendia, Inc. , a world leader in precision oncology for breast cancer, today shared data demonstrating the ability of MammaPrint® and BluePrint® to predict patient outcomes following neoadjuvant chemotherapy (NAC) at the 2021 San Antonio Breast Cancer Symposium (SABCS 2021).
The poster, titled MammaPrint and BluePrint are prognostic of outcome following neoadjuvant chemotherapy , presents findings that indicate MammaPrint and BluePrint accurately correlated with chemosensitivity and outcomes in NAC-treated patients. The research was conducted in collaboration with Cedars-Sinai Medical Center.
Notably, approximately 1 in 4 tumors which were MammaPrint High Risk (Luminal B) prior to NAC became MammaPrint Low Risk (Luminal A) when the post-treatment tissue was analyzed. Patients with reclassified MammaPrint Low Risk tumors had improved five-year outcomes compared to patients that remained High Risk after treatment. These data signal a role for serial genomic testing to determine proper classification of breast cancer tumors following NAC treatment in order to appropriately manage a woman’s future treatment plan and prognosis.
“By analyzing MammaPrint and BluePrint on pre- and post-NAC tissue samples for those with residual disease, we unlock new insights about their clinical utility and potential impact on treatment decisions given the biological changes that may occur following initial intervention,” said Alice P. Chung, MD, Division of Surgical Oncology, Department of Surgery, Cedars-Sinai Medical Center. “The importance of accurate genomic classification of a tumor is crucial, especially in the context of these findings where 1 in 4 High Risk tumors became Low Risk – insights which can significantly affect our treatment planning discussions with patients.”
The analysis presented at SABCS 2021 features data from 128 women (median age 50) with stage I-III early breast cancer (EBC), of any clinical subtype, diagnosed from 2007-2016 who received NAC at Cedars-Sinai Medical Center. Among 111 pre-treated tumors, MammaPrint High Risk tumors had a significantly higher pathological complete response (pCR) rate than Low Risk tumors. Amongst tumors that had discordant MammaPrint results between pre- and post-treatment samples, the only change observed was from High Risk to Low Risk. BluePrint results were very consistent between pre- and post-NAC samples (92% concordance) with reclassification only occurring in the HER2-Type cohort, consistent with the known heterogeneity in clinically HER2-positive tumors.
“Neoadjuvant chemotherapy is the standard of care for the initial treatment of certain types of breast cancer, and for many women, the clinical response to therapy is thought to carry prognostic implications. This study illustrates the additional information provided by our genomic assays regarding response to therapy and prognosis,” said William Audeh, MD, Chief Medical Officer at Agendia and a study author. “While changes in the MammaPrint Risk index with treatment are clearly associated with outcome, it is also important to note the consistency of BluePrint results pre- and post- treatment with neoadjuvant chemotherapy. These data further demonstrate the prognostic accuracy of the assays and confirm the importance of genomic information in our quest to identify better biomarkers in patients treated with neoadjuvant chemotherapy.”
Future studies will study the effect of NAC on the breast cancer transcriptome and its association with clinical outcomes.
About Agendia
Agendia is a mission-driven company focused on enabling optimized treatment planning by providing physicians with next-generation diagnostic and information solutions that can be used to help improve outcomes and quality of life for breast cancer patients worldwide. The company currently offers two commercially-available genomic profiling tests that help surgeons, oncologists and pathologists to personalize treatment for women at critical intervention points throughout their patient journey.
MammaPrint® is a 70-gene prognostic test that, along with other clinicopathologic factors, determines a specific patient’s breast cancer recurrence risk. BluePrint® is an 80-gene molecular subtyping test that identifies the underlying biology of an individual breast cancer to provide information about its behavior, long-term prognosis and potential response to systemic therapy. Together, MammaPrint® and BluePrint® provide a holistic view of an individual patient’s breast cancer, enabling physicians to objectively select the best treatment plan.
For more information on Agendia’s assays and ongoing trials, please visit www.agendia.com .
View source version on businesswire.com: https://www.businesswire.com/news/home/20211209006022/en/
Link:
About Business Wire
Subscribe to releases from Business Wire
Subscribe to all the latest releases from Business Wire by registering your e-mail address below. You can unsubscribe at any time.
Latest releases from Business Wire
Thales Selected to Deliver Next-Generation Mine-Hunting Capability for the U.S. Navy2.11.2026 07:00:00 CET | Press release
Thales’ subsidiary Advanced Acoustic Concepts (AAC) won a $53.9 million U.S. Navy contract for two Remote Mine Hunting (RMH) modules and engineering support, with options increasing the potential value to $196.2 million for additional modules. The RMH solution enhances unmanned Mine Countermeasures (MCM) by enabling remote detection and classification and supporting rapid threat engagement, while reducing risk to sailors and platforms. The contract reinforces Thales’ position in MCM and undersea warfare, leveraging international expertise and American innovation to rapidly deliver critical capabilities that enhance U.S. Navy operational readiness and sailor safety in contested maritime environments. Thales’ subsidiary Advanced Acoustic Concepts (AAC), a U.S.-based provider of undersea warfare solutions, was awarded a $53.9 million U.S. Navy contract to produce and deliver two integrated Remote Mine Hunting (RMH) modules and accompanying engineering support. The award includes options f
Uptime Institute and Indonesia Ministry of Communication and Digital Affairs (KOMDIGI) Sign Letter of Intent (LOI) to Support Data Center Policy, Governance, and Industry Development2.11.2026 06:04:00 CET | Press release
Uptime Institute, the Global Digital Infrastructure Authority, and the Ministry of Communication and Digital Affairs (Komdigi) today announced the signing of a Letter of Intent (LOI) to explore collaboration aimed at strengthening Indonesia's data center ecosystem through policy development, governance frameworks, operational excellence, security, sustainability, and workforce capability development. This press release features multimedia. View the full release here: https://www.businesswire.com/news/home/20261101628182/en/ Uptime Institute and KOMDIGI sign LOI. The Letter of Intent reflects a shared interest in exploring international best practices that may support the development of reliable, secure, efficient, and sustainable digital infrastructure aligned with Indonesia's national priorities and regulatory framework. The LOI was signed by Mustapha Louni, Chief Business Officer, Uptime Institute, and Wayan Toni Supriyanto, Director General of Digital Infrastructure, Indonesia's Min
Uptime Institute Signs Memorandum of Understanding (MOU) with Indonesian Data Center Providers Association (IDPRO) to Advance Indonesia's Data Center Industry2.11.2026 06:02:00 CET | Press release
Uptime Institute, the Global Digital Infrastructure Authority, today announced the signing of a Memorandum of Understanding (MOU) with the Indonesia Data Center Provider Organization (IDPRO) to support the development of a reliable, sustainable, and globally competitive data center industry in Indonesia. IDPRO is the official industry association representing data center providers and digital infrastructure companies in Indonesia. This press release features multimedia. View the full release here: https://www.businesswire.com/news/home/20261101556619/en/ Signing of Uptime Institute and IDPRO MOU. The goal of the collaborative agreement between the two organizations is to promote international standards and best practices in Indonesia across the data center lifecycle, strengthening infrastructure availability and operational resilience, advancing resource efficiency and sustainability, and supporting the development of a skilled industry workforce. These priorities will help raise indus
AIT Worldwide Logistics Expands Global Footprint to Oceania with Acquisition of Australia-Based Forwarder Connor Anderson International2.11.2026 05:01:00 CET | Press release
Strategic investment increases AIT’s geographic reach, high-tech logistics support capabilities Supply chain solutions leader AIT Worldwide Logistics (“AIT”) has finalized an agreement to acquire Connor Anderson International (“CAI”), a global freight forwarder based in Sydney. This press release features multimedia. View the full release here: https://www.businesswire.com/news/home/20261028626874/en/ Acquiring Connor Anderson International serves as the foundation for AIT's long-term expansion to serve Oceania more broadly. Founded in 1974, CAI delivers comprehensive logistics support, including sea, air and road transport, customs brokerage, warehousing, and project cargo management for customers across a wide range of industries. Notably, CAI’s long-tenured team manages a wide variety of specialized cargo while increasingly emphasizing distinctive services for technology companies serving the Australia and broader Oceania markets. The acquisition will strengthen AIT’s specialized se
MultiBank Exchange, Part of MultiBank Group, Unveils World’s Fastest Interbank Matching Engine and Digital Asset Settlement2.11.2026 03:00:00 CET | Press release
Platform connects more than 30 tier-one banks and liquidity providers, combining 400-nanosecond matching with credit services and settlement in fiat currencies and digital assets Board of Directors of MultiBank Exchange Holding formed, chaired by Naser Taher MultiBank Exchange, part of MultiBank Group, one of the world’s largest financial derivatives institutions, has announced the world’s first interbank trading platform to offer double exotic currency pairs with settlement in both fiat currencies and digital assets. This press release features multimedia. View the full release here: https://www.businesswire.com/news/home/20261101073341/en/ MultiBank Exchange is designed to connect banks and financial institutions across the GCC, BRICS and other emerging markets with Western trading technology and global liquidity. Its objective is to enable these institutions to participate in international foreign exchange markets on an equal footing with their Western counterparts. With daily tradi
In our pressroom you can read all our latest releases, find our press contacts, images, documents and other relevant information about us.
Visit our pressroom