AlzeCure Pharma
5.10.2021 10:16:39 CEST | ACCESS Newswire | Press release
STOCKHOLM, SE / ACCESSWIRE / October 5, 2021 / AlzeCure Pharma (STO:ALZCUR)(FRA:AC6)
AlzeCure Pharma AB (publ) (FN STO:ALZCUR), a pharmaceutical company that develops a broad portfolio of candidate drugs for diseases affecting the central nervous system, with projects in both Alzheimer's disease and pain, today announced that the company's presentation and poster regarding the research platform in neurology, NeuroRestore, its connection to BDNF/TrkB signaling and potential therapeutic role in depression, as presented at the European College of Neuropsychopharmacology (ECNP) 2021 on 2-5 October in Lisbon, Portugal, are now available in its entirety on the company's website.
The abstract, titled Characterization of positive allosteric modulators of TrkB for the treatment of depression , was presented by Johan Sandin, Chief Scientific Officer, and contains new data showing how substances from the NeuroRestore platform affect relevant signaling pathways in the brain and have effects in various preclinical models that link to depression.
These substances stimulate signaling through the receptors for the neurotrophin BDNF, so-called TrkB receptors. This biological system has been linked to depression, and the support for this hypothesis has been further strengthened in recent times and new scientific findings indicate that many of the classic antidepressant drugs available today actually mediate their effect via BDNF/TrkB*. In addition, the substances also show a positive effect on cognitive ability, such as memory and learning - functions that can also be affected in depression.
"NeuroRestore, with the primary candidate drug ACD856, acts as a BDNF/NGF signaling enhancer and can be used in various types of cognitive impairments in which the same signal pathway is reduced. We have previously seen that NeuroRestore compounds have had significant effects in preclinical models of depression and it is very exciting that we, with these findings, get further scientific support for the effect," said Johan Sandin, CSO at AlzeCure Pharma.
"The findings we have seen with our substances indicate that there are also great opportunities for the NeuroRestore platform in other cognitive disorders outside Alzheimer's. Depression is an area with great medical needs and affects people at a young age," said Martin Jönsson, CEO of AlzeCure Pharma.
The authors of the abstract include Johan Sandin, Chief Scientific Officer at AlzeCure, Dr. Pontus Forsell, Head of Discovery, Dr. Gunnar Nordvall, Head of Chemistry and Magnus Halldin, Head of DMPK & Safety at AlzeCure.
The presentation, the poster and the abstract are available on AlzeCure's website: ( https://www.alzecurepharma.se/en/presentations-and-interviews/ ).
*) Casarotto et al., 2021, Antidepressant drugs act by directly binding to TRKB neurotrophin receptors, Cell 184, 1299-1313, March 4, 2021, https://www.cell.com/cell/pdf/S0092-8674(21)00077-5.pdf
For more information, please contact
Martin Jönsson, CEO
Tel: +46 707 86 94 43
martin.jonsson@alzecurepharma.com
About AlzeCure Pharma AB (publ)
AlzeCure® is a Swedish pharmaceutical company that develops new innovative drug therapies for the treatment of severe diseases and conditions that affect the central nervous system, such as Alzheimer's disease and pain - indications for which currently available treatment is very limited. The company is listed on Nasdaq First North Premier Growth Market and is developing several parallel drug candidates based on three research platforms: NeuroRestore®, Alzstatin® and Painless.
NeuroRestore consists of two symptomatic drug candidates where the unique mechanism of action allows for multiple indications, including Alzheimer's disease, as well as cognitive disorders associated with traumatic brain injury, sleep apnea and Parkinson's disease. The Alzstatin platform focuses on developing disease-modifying and preventive drug candidates for early treatment of Alzheimer's disease and comprises two drug candidates. Painless is the company's research platform in the field of pain and contains two projects: ACD440, which is a drug candidate in the clinical development phase for the treatment of neuropathic pain, and TrkA-NAM, which targets severe pain in conditions such as osteoarthritis. AlzeCure aims to pursue its own projects through preclinical research and development to an early clinical phase, and is continually working on business development to find suitable outlicensing solutions with other pharmaceutical companies.
FNCA Sweden AB, +46(0)8 528 00 399 info@fnca.se, is the company's Certified Adviser. For more information, please visit www.alzecurepharma.se.
About NeuroRestore
NeuroRestore is a platform of symptom-relieving drug candidates for disease states in which cognitive ability is impaired, e.g. Alzheimer's Disease, sleep apnea, traumatic brain injury and Parkinson's disease. NeuroRestore stimulates several important signaling pathways in the brain, which among other things leads to improved cognition. In preclinical studies with NeuroRestore we have been able to show that our drug candidates enhance communication between the nerve cells and improve cognitive ability. NeuroRestore stimulates specific signaling pathways in the central nervous system known as neurotrophins, the most well-known being NGF (Nerve Growth Factor) and BDNF (Brain Derived Neurotrophic Factor). The levels of NGF and BDNF are disturbed in several disease states and the signaling is reduced. The impaired function impairs communication between the synapses, i.e. the contact surfaces of the nerve endings, as well as reducing the possibility of survival for the nerve cells, which gives rise to the cognitive impairments. Neurotrophins play a crucial role for the function of nerve cells, and a disturbed function of BDNF has a strong genetic link to impaired cognitive ability in several different diseases, such as Alzheimer's, Parkinson's disease, traumatic brain injury and sleep disorders. There is also a link between BDNF signaling and depression, something that has been further strengthened in recent years.
About Alzheimer's disease
Alzheimer's disease is the most common form of dementia, affecting approximately 50 million people worldwide. Alzheimer's disease is a lethal disorder that also has a large impact on both relatives and the society. Today, preventive and disease modifying treatments are missing. The main risk factors to develop Alzheimer's are age and genetic causes. Even though the disease can start as early as between 40 and 65 years of age, it is most common after 65 years. Significant investments in Alzheimer research are being made because of the significant unmet medical need and the large cost of this disease for healthcare and society. The total global costs for dementia related diseases is estimated to about 1,000 billion USD. Given the lack of both effective symptomatic treatments and disease modifying treatments, the need for new effective therapies is acute. The few approved drugs on the market today have only a limited symptomatic effect and can produce dose limiting side effects. A disease modifying treatment for Alzheimer's disease is estimated to reach more than $15 billion in annual sales. In Sweden, approximately 100,000 people suffer from Alzheimer's disease with a healthcare cost of about SEK 63 billion yearly, which is more than for cancer and cardiovascular diseases combined.
Image Attachments
Martin Jönsson CEO And Johan Sandin CSO AlzeCure Pharma
Attachments
SOURCE: AlzeCure Pharma
View source version on accesswire.com:
https://www.accesswire.com/666797/New-Data-Showing-the-Potential-of-the-NeuroRestore-Project-in-Depression-Presented-at-ECNP-2021-Conference
To view this piece of content from www.accesswire.com, please give your consent at the top of this page.
About ACCESS Newswire
Subscribe to releases from ACCESS Newswire
Subscribe to all the latest releases from ACCESS Newswire by registering your e-mail address below. You can unsubscribe at any time.
Latest releases from ACCESS Newswire
Northfield's Flagship Investment Juno Corp. Discovers Heavy Rare Earth Magnet Metals at Vespa19.5.2026 13:01:00 CEST | Press release
Broadens Juno's Polymetallic Critical Minerals System in Ontario's Ring of Fire TORONTO, ON / ACCESS Newswire / May 19, 2026 / Northfield Capital Corporation ("Northfield" or the "Company") (TSXV:NFD.A) is pleased to comment on the announcement made today by Juno Corp. ("Juno") regarding the discovery of heavy rare earth element ("HREE") mineralization, including the magnet metals neodymium, praseodymium, dysprosium and terbium, within Juno's Vespa critical minerals system in Ontario's Ring of Fire (the "Juno Announcement"). For the full text of the Juno Announcement, including the technical disclosure relating to drill hole VES-26-025 and the associated assay results, please refer to Juno's press release dated May 19, 2026, available at www.junocorp.com. Northfield holds an approximately 35% equity interest in Juno, making Juno one of the most significant investments in Northfield's portfolio. The discovery disclosed in the Juno Announcement broadens the polymetallic critical minerals
Juno's Vespa Critical Minerals Discovery Expands to Include Heavy Rare Earth Magnet Metals19.5.2026 13:00:00 CEST | Press release
New Discovery Adds the Metals at the Centre of Global Supply Concerns TORONTO, ON / ACCESS Newswire / May 19, 2026 / Juno Corp. ("Juno" or the "Company") today announced the discovery of heavy rare earth elements - including the magnet metals essential to defence, aerospace, electric vehicles and clean energy - within its Vespa critical minerals system in Ontario's Ring of Fire. The discovery sits within the same geological system as Juno's previously announced high-grade iron, titanium, vanadium, scandium and gallium intercepts at Vespa, broadening the critical minerals discoveries. "Rare earth magnet metals are the materials that build modern defence systems, fighter jets, electric vehicles and clean energy infrastructure. Global supply is dominated by a single country that has shown its willingness to use export controls as a tool of geopolitical leverage - making secure, allied sources of these metals a national priority for Canada, the United States and our partners," said Robert
LiberNovo 2026 Triple Launch: SE, Pro, and Maxis Introduce Dynamic Ergonomics for Every Body Type Across Europe18.5.2026 19:00:00 CEST | Press release
LONDON, GB / ACCESS Newswire / May 18, 2026 / LiberNovo, the premium ergonomic chair brand pioneering movement-based seating, today confirmed the full details of its 2026 product expansion for the European market. Three new lines-the Omni SE, Omni Pro, and the all-new Maxis series-will be available to customers across the UK and EU starting June 16, with pre-orders now open. Across Europe, the shift toward hybrid and remote work has turned the home office into a permanent fixture. Yet the chair at the centre of that setup is often the last thing to be upgraded. Most ergonomic seating still operates on a decades-old premise: find the correct posture, lock it in, stay put. LiberNovo rejects that model entirely. Its Dynamic Ergonomics platform is built around continuous adaptation-chairs that respond to how users actually move through their day, rather than forcing them into a fixed position. With three distinct product lines, that approach now reaches users of every build and budget. Omn
Europe's Healthcare IT Market Enters the 2027 Readiness Cycle as Black Book Names 26 Top Client-Rated Vendors During HIMSS26 Week in Copenhagen18.5.2026 18:00:00 CEST | Press release
Category-specific honors identify client-rated leaders in data-ready EHRs, interoperability, enterprise imaging, cloud, cybersecurity, AI, advisory, analytics, clinical decision support and digital health infrastructure COPENHAGEN, DK / ACCESS Newswire / May 18, 2026 / Black Book Research today announced its 2026 European Healthcare IT Client Satisfaction Honors, recognizing 26 healthcare technology vendors and platforms whose strongest client-facing performance aligns with the next phase of European digital health: trusted data, cross-border interoperability, AI accountability, cybersecurity resilience, cloud modernization, enterprise imaging liquidity, analytics readiness and clinical workflow transformation. The announcement is timed to HIMSS26 Europe, taking place 19-21 May 2026 at the Bella Center in Copenhagen, Denmark, where healthcare leaders, innovators and policymakers are convening around digital maturity, AI, interoperability, cybersecurity and health system transformation.
Tyson Fury, The Gypsy King, Joins Datavault AI as International Spokesperson to Champion Athlete Data Monetization18.5.2026 14:37:00 CEST | Press release
Forbes' Third Highest-Paid Athlete in the World Brings Global Platform to Datavault AI's Sports Illustrated Exchange and NIL Monetization Initiative PHILADELPHIA, PA / ACCESS Newswire / May 18, 2026 / Datavault AI Inc. ("Datavault AI" or the "Company") (NASDAQ:DVLT), a provider of data monetization, credentialing, digital engagement, and real-world asset (‘RWA') tokenization technologies, today announced that two-time world heavyweight champion Tyson Fury has signed on as International Spokesperson for Datavault AI a deal brokered by Nick Hunter of P11. Ranked No. 3 on Forbes' 2025 list of the world's highest-paid athletes with $146 million in estimated earnings (Forbes 2025), Fury brings global star power, and a uniquely personal understanding of what it means to own, protect, and capitalize on a name, to Datavault AI's mission of empowering individuals and organizations to monetize their data and digital assets. Known worldwide as "The Gypsy King," his appointment immediately precede
In our pressroom you can read all our latest releases, find our press contacts, images, documents and other relevant information about us.
Visit our pressroom