ADC Therapeutics Doses First Patient in Phase I Trial of ADCT-301 Trial in Acute Myeloid Leukemia
ADC Therapeutics SA (ADCT), the oncology drug development company, announces that the first patient has been dosed in a Phase I trial to evaluate its lead antibody drug conjugate (ADC) ADCT-301 in Acute Myeloid Leukemia (AML).
The two stage, Phase l open-label trial will evaluate the tolerability, safety, pharmacokinetics and activity of ADCT-301 in patients with relapsed or refractory CD-25 positive AML. The initial dose escalation phase will recruit up to 30 patients at ten clinical sites across the US and will seek to determine the recommended dose of ADCT-301 for the second stage. The second stage, which will begin once an appropriate dose is identified, will be expanded into the UK and Europe with the recruitment of up to 30 additional patients.
ADCT-301 is composed of HuMax® -TAC, a monoclonal antibody directed against CD25 (the alpha chain of the IL-2 receptor) conjugated to ADCT’s highly potent proprietary pyrrolobenzodiazepine (PBD) dimer. In preclinical in vivo models, ADCT-301 exhibited strong dose-dependent anti-tumor activity against CD25-positive cell lines at single low doses.
Professor Martin Tallman, Principle Investigator of the trial and Chief of the Leukemia Service at Memorial Sloan Kettering Cancer Center, New York, said: “Acute myeloid leukemia is the most common leukemia in the US adult population and the prognosis is poor. Patients expressing CD25 on their leukemia cells have a particularly poor prognosis.
ADCT-301 has shown promise in in vivo studies and we believe that this important trial could help us to improve patient outcomes.”
Dr Chris Martin, CEO of ADC Therapeutics, added: “Dosing the first patient in this trial with ADCT-301 is an important milestone for the Company. We look forward to the progress of this trial over the coming year and to accelerating the clinical development of our ADC pipeline.”
ADC Therapeutics currently has two PBD-based ADCs in four clinical trials, with four other ADCs in late preclinical development and further ADCs in research.
Notes to Editors
About ADC Therapeutics ( www.adctherapeutics.com )
ADC Therapeutics SA (ADCT) is an oncology drug development company that specializes in the development of proprietary ADCs targeting major solid and hematological cancers. The Company’s ADCs are highly targeted drug constructs which combine monoclonal antibodies specific to surface antigens present on particular tumor cells with a novel class of highly potent pyrrolobenzodiazepine (PBD)-based warheads. The Company has access to warhead and linker chemistries via agreements with Spirogen (a wholly-owned subsidiary of AstraZeneca’s MedImmune). It is progressing eleven ADC programs, one of these under a joint development agreement with MedImmune. During 2015 ADCT-301 and ADCT-402 entered Phase I for lymphoma and leukemia. ADC Therapeutics has its head office in Lausanne, Switzerland and has its R&D laboratories in London, UK, its clinical development team in New Jersey, USA, and its manufacturing team based in San Francisco, USA.
Sue Charles / Gemma Howe
T: +44 (0)20 7866 7860
Instinctif Partners – Switzerland
T: +41 (0) 44 280 11 86
Information om Business Wire
101 California Street, 20th Floor
CA 94111 San Francisco
Følg pressemeddelelser fra Business Wire
Skrive dig op her og du vil løbende modtage pressemeddelelser på mail. Indtast din mail, klik på abonner og følg instruktionerne i den udsendte mail.
Flere pressemeddelelser fra Business Wire
TAKEDA15.12.2017 13:36 | pressemeddelelse
Takeda and TiGenix announce that Cx601 (darvadstrocel) has received a positive CHMP opinion to treat complex perianal fistulas in Crohn’s disease
TWISPAY15.12.2017 13:23 | pressemeddelelse
Bitcoin Romania and Twispay Announce Integration Partnership Providing Users with the Ability to Purchase Bitcoin with Bank Cards
PEACE-FORUM15.12.2017 12:40 | pressemeddelelse
Upon Conclusion of the Fourth Annual Forum for Promoting Peace in Muslim Societies, Scholars and Intellectuals Visit the Louvre Abu Dhabi Museum
CA-KENNEDY-WILSON15.12.2017 12:02 | pressemeddelelse
Kennedy Wilson Acquires 124-Unit Northbank Apartments in Dublin, Ireland for €45 Million
NV-NAC-FOUNDATION15.12.2017 10:02 | pressemeddelelse
AML BitCoin Enters Phase II of ICO
THE-CITY-OF-JOENSUU15.12.2017 09:26 | pressemeddelelse
Joensuu City Challenge – International Competition for Innovative SMEs Opened
I vores nyhedsrum kan du læse alle vores pressemeddelelser, tilgå materiale i form af billeder og dokumenter, og finde vores kontaktoplysninger.Besøg vores nyhedsrum