Merck Launches Single-Use Reactor Designed to Accelerate Antibody Drug Conjugate Manufacturing
First scalable single-use mixer specifically designed for ADC manufacturing Increases efficiency by 70% compared to stainless steel or glass manufacturing methods Utilizes Ultimus® Film for superior leak resistance
Merck, a leading science and technology company, launched the first single-use reactor specifically designed to manufacture antibody drug conjugates (ADCs). ADCs are a rapidly emerging class of therapeutic agents that can target and selectively kill tumor cells, while protecting healthy ones. The Mobius® ADC Reactor is tailored precisely to meet the unique requirements for linking the necessary components. It enables biopharmaceutical companies to produce their critical therapies faster and safer.
This press release features multimedia. View the full release here: https://www.businesswire.com/news/home/20240910038674/en/
Merck's new Mobius® ADC Reactor is the first scalable single-use mixer specifically designed for antibody drug conjugate manufacturing. (Photo: Business Wire)
“We have been providing single-use solutions for flexible biopharmaceutical manufacturing for more than 15years. Drawing on this extensive experience, we are now ready to accelerate the production of antibody-drug conjugates," said Sebastian Arana, Head of Process Solutions for the Life Science business of Merck. "The launch of the Mobius® ADC Reactor will support our customers to bring much-needed therapies to a global population.”
Current ADC production methods use stainless steel or glass reactors which require labor-intensive and costly cleaning procedures. Single-use technology costs less, reduces risk, and is more flexible and faster than these traditional methods. However, the adoption of this technology in ADC manufacturing has been limited due to the unique chemical compatibility and quality requirements. The Mobius® ADC Reactor changes this by offering faster turnaround times and fewer cross-contamination risks, all while maintaining high product quality. Performance improvements include elimination of potent liquid waste and a 70% increase in efficiency. Additionally, the new reactor’s single-use assemblies are made of Ultimus® Film technology, providing enhanced bag strength, improved durability, and leak resistance.
Merck offers a wide range of solutions tailored to the specific requirements of ADC manufacturing. For purification processes, these include the Mobius® single-use systems for chromatography and tangential flow filtration (TFF), particularly used in closed-mode operations, paired with consumables such as the Pellicon® capsule. Merck also offers contract development and manufacturing organization (CDMO) and testing services for ADCs and high-potent active pharmaceutical ingredients (HPAPIs.)
Antibody Drug Conjugates
Antibody drug conjugates (ADCs) are medicines that target specific cells in the body, such as cancer cells. They work by combining a monoclonal antibody (mAb), which acts like a guide, with a drug. The mAb finds and attaches itself to certain antigens found on the surface of targeted cells. This allows the drug to be delivered directly to the targeted cell, resulting in cell death. Damage to surrounding healthy cells is minimized. This targeted approach means fewer side effects compared to other treatments. ADCs therefore offer a way to treat diseases more precisely and safely.
Due to their promise for patients, ADCs have experienced incredible growth over the years, with 13 ADCs currently approved by the FDA, eight of which have been approved since 20191.
About Merck
Merck, a leading science and technology company, operates across life science, healthcare and electronics. Around 63,000 employees work to make a positive difference to millions of people’s lives every day by creating more joyful and sustainable ways to live. From providing products and services that accelerate drug development and manufacturing as well as discovering unique ways to treat the most challenging diseases to enabling the intelligence of devices – the company is everywhere. In 2023, Merck generated sales of € 21 billion in 65 countries.
Scientific exploration and responsible entrepreneurship have been key to Merck’s technological and scientific advances. This is how Merck has thrived since its founding in 1668. The founding family remains the majority owner of the publicly listed company. Merck holds the global rights to the Merck name and brand. The only exceptions are the United States and Canada, where the business sectors of Merck operate as MilliporeSigma in life science, EMD Serono in healthcare, and EMD Electronics in electronics.
All Merck press releases are distributed by e-mail at the same time they become available on the Merck website. Please go to www.merckgroup.com/subscribe to register online, change your selection or discontinue this service.
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1https://broadpharm.com/blog/ADC-Approval-up-to-2023
View source version on businesswire.com: https://www.businesswire.com/news/home/20240910038674/en/
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Media Relations
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Phone: +49 (6151) 72-44461
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