OWKIN/IDORSIA
Owkin, the first end-to-end TechBio unicorn that uses cutting-edge causal AI to unlock precision drug discovery, development and diagnostics, has unveiled an innovative drug pipeline in oncology and immunology following an exclusive global licensing agreement with Idorsia (SIX: IDIA) to develop and commercialize OKN4395, a clinic-ready best-in-class dual inhibitor of prostanoid receptors EP2 and EP4.
This press release features multimedia. View the full release here: https://www.businesswire.com/news/home/20240523897876/en/
Unveiling Owkin’s AI precision pipeline
Owkin’s unique pipeline is the product of several internal AI engines powered by multimodal patient data from a network of 61 leading research centers and cutting-edge AI from a team of 110 data scientists that have published 57 top publications. Owkin’s pipeline is differentiated by the use of spatial multiomics data via MOSAIC, the world's largest spatial multiomics dataset in oncology that enables Owkin to capture the tumor microenvironment in a way that few others can. With deep immune response expertise in T-cell connectivity and seven years of successful AI drug discovery projects internally and with leading pharma partners, Owkin is poised to tackle some of the most critical challenges in precision medicine.
OKN4395 is the result of 10 years of drug discovery by experts at Idorsia and external collaborators. Owkin believes this asset has the potential to be a best-in-class dual inhibitor of the very challenging EP2 and EP4 targets thanks to years of medicinal chemistry, a feat that Generative AI has yet to achieve.
Thomas Clozel, MD, CEO & Co-founder: “Our AI-powered precision pipeline demonstrates our dedication to tailoring treatments to specific patient subgroups by using causal biomarkers from patient data. This is how Owkin is driving a paradigm shift in precision health. As a physician, I am proud that we can now extend our pipeline from AI-target discovery and lab validation to clinical trials, getting closer to the ground truth of biology and providing clinical benefits to patients sooner.”
Owkin’s AI Engines select OKN4395 for in-licensing
Owkin’s biomarker engine used multimodal patient data to create detailed signatures of EP2/EP4 biology, combining histology and molecular profiles. This helped identify actionable biomarkers for indication selection and clinical trial development.
Owkin’s AI drug positioning engine then screened over 30 cancer indications for OKN4395, ranking them based on their relevance to the EP2/EP4 pathway. This data-driven process, validated by medical experts, identified the most promising therapeutic combinations for clinical trial success, synergising with traditional expert-driven approaches.
Vassili Soumelis, MD, PhD, Owkin Chief Medical Officer: “Our AI engines integrated rich multimodal patient data from multiple cancer indications, allowing us to discover that EP2/EP4 biology significantly perturbs T cell connectivity within the tumor microenvironment (TME) through direct and indirect mechanisms.”
To de-risk OKN4395’s clinical trial, Owkin will apply AI to build an external control arm in phase 1B and use multimodal patient data to select optimal inclusion/exclusion criteria and prognostic covariates to strengthen the treatment signal in a data-driven way.
Andrew J. Pierce, PhD, SVP Discovery & Development: “As a result of extensive in-house medical chemistry expertise, Idorsia had a very potent dual inhibitor of EP2/EP4, which came with a compelling preclinical dataset including restoration of T cell functionality. With this best-in-class asset, Owkin can now unleash its capacity to decipher complex biology to get us one step closer to finding the right treatment for every patient.”
Leveraging world-leading data access and cutting-edge technologies, Owkin’s pipeline promises a unique approach to tackle some of the most critical challenges in precision medicine. To expand its pipeline further, Owkin intends to harness its AI engines to supplement in-house drug discovery with in-licensed assets in oncology, immunology, and inflammation.
About Owkin
Owkin is the first end-to-end TechBio unicorn on a mission to understand complex biology and derive new multimodal biomarkers through AI. We identify precision therapeutics, de-risk and accelerate clinical trials and develop diagnostics using AI trained on world-class patient data through privacy-enhancing federated technologies. We merge wet lab experiments with advanced AI techniques to create a powerful feedback loop for accelerated discovery and innovation in oncology, cardiovascular disease, immunity and inflammation. Owkin also founded MOSAIC, the world’s largest spatial multiomics atlas for cancer research. Owkin has raised over $300 million through investments from leading biopharma companies, including Sanofi and BMS, and venture funds like Fidelity, GV and Bpifrance, among others.
About Idorsia
Idorsia Ltd is reaching out for more – We have more ideas, we see more opportunities and we want to help more patients. In order to achieve this, we will develop Idorsia into a leading biopharmaceutical company, with a strong scientific core.
Headquartered near Basel, Switzerland – a European biotech-hub – Idorsia is specialized in the discovery, development and commercialization of small molecules to transform the horizon of therapeutic options. Idorsia has a 25-year heritage of drug discovery, a broad portfolio of innovative drugs in the pipeline, an experienced team of professionals covering all disciplines from bench to bedside, and commercial operations in Europe and North America – the ideal constellation for bringing innovative medicines to patients.
Idorsia was listed on the SIX Swiss Exchange (ticker symbol: IDIA) in June 2017 and has over 750 highly qualified specialists dedicated to realizing our ambitious targets.
To view this piece of content from cts.businesswire.com, please give your consent at the top of this page.
View source version on businesswire.com: https://www.businesswire.com/news/home/20240523897876/en/
About Business Wire
Subscribe to releases from Business Wire
Subscribe to all the latest releases from Business Wire by registering your e-mail address below. You can unsubscribe at any time.
Latest releases from Business Wire
MultiBank Group Confirms $MBG Token TGE Set for July 22, 202512.7.2025 11:14:00 CEST | Press release
MultiBank Group, the world’s largest financial derivatives institution has officially announced that the Token Generation Event (TGE) for its highly anticipated $MBG Token will take place on July 22, 2025. This press release features multimedia. View the full release here: https://www.businesswire.com/news/home/20250712404220/en/ MultiBank Group has officially announced that the Token Generation Event (TGE) for its highly anticipated $MBG Token will take place on July 22, 2025. This milestone will mark the full activation of the $MBG Token on the blockchain, enabling holders to view and manage their balances across supported platforms. Following the token minting, users will be able to trade $MBG via MultiBank.io, the Group’s regulated crypto exchange and Uniswap, the world’s leading decentralized platform. The $MBG Token has garnered global attention for its rare combination of real-world utility, institutional backing, and strong deflationary mechanics. It is underpinned by $29 billi
Elegen and Nutcracker Therapeutics to Pilot First Fully Cell-Free Manufacturing Process for RNA-based Personalized Cancer Therapeutics11.7.2025 14:00:00 CEST | Press release
Fully cell-free process aims to further democratize personalized cancer therapeutic manufacturing with shorter turnaround times and negligible bioburden and endotoxin risks. Elegen, a global leader in next-generation DNA manufacturing, and Nutcracker Therapeutics, a global leader in next-generation RNA design and manufacturing, today announced the launch of a pilot program to demonstrate the industry’s first fully synthetic, cell-free manufacturing platform for RNA-based personalized cancer therapeutics (PCTs). The pilot marks another step toward making PCTs more accessible, timely, and scalable. This press release features multimedia. View the full release here: https://www.businesswire.com/news/home/20250711152688/en/ As late-stage PCT clinical trials progress and therapy developers work to create the next generation of PCTs, the speed, reliability, scaling and cost of traditional production methods pose a major challenge. Specifically, the first step of DNA template production is hi
$MBG Token Pre-Sale Set for July 15 — Only 7 Million Tokens Available at $0.3511.7.2025 10:17:00 CEST | Press release
MultiBank Group, the world’s largest financial derivatives institution headquartered in Dubai, has confirmed that its highly anticipated $MBG Token pre-sale will go live on July 15, with demand expected to be intense. This press release features multimedia. View the full release here: https://www.businesswire.com/news/home/20250711737311/en/ With only 7 million $MBG tokens up for grabs at an exclusive entry price of $0.35, this is a rare opportunity to secure early access to what many are calling the year’s most powerful utility asset. With only 7 million tokens up for grabs at an exclusive entry price of $0.35, this is a rare opportunity to secure early access to what many are calling the year’s most powerful utility asset. Early participants can join simultaneously on MultiBank.io, the Group’s regulated crypto exchange, and Uniswap, the world’s leading decentralized platform. Supported by $29 billion in real assets and powered by over $35 billion in daily turnover, $MBG is engineered
Live Story Raises €2.7 Million to Revolutionize the Digital Experience11.7.2025 10:05:00 CEST | Press release
With a round led by Vertis, the next-generation CMS platform accelerates its focus onAI, performance, and European expansion. Target: surpass €10M in recurring revenueby 2027. Live Story, the tech company founded by Stefano Mocellini, has closed a €2.7 million seed round led by Vertis, one of Italy’s leading early-growth venture capital firms. The funding will support the company’s international expansion and technological development, with a clear goal: to exceed €10 million in annual recurringrevenue by 2027. This press release features multimedia. View the full release here: https://www.businesswire.com/news/home/20250711335560/en/ “We invested in Live Story because it addresses one of the major inefficiencies in digital commerce: the slow and rigid management of visual and narrative content,” says Alessandro Pontari, Partner at Vertis SGR. “The platform helps brands drastically reduce their time-to-market through a visual CMS that integrates seamlessly with any tech stack. In a wor
With a Score of 84 out of 100, Sagemcom Is Awarded the EcoVadis Platinum Medal: a Prestigious Recognition of its CSR Commitment11.7.2025 09:00:00 CEST | Press release
Sagemcom Group is proud to announce that it has been awarded, for the third time, the Platinum Medal by EcoVadis, the highest distinction granted by the leading global platform for assessing Corporate Social Responsibility (CSR) performance. This medal places Sagemcom in the top 1% of companies evaluated worldwide, across all industries. With a score of 84 out of 100, Sagemcom reaffirms its position as a committed leader in ecological transition, business ethics, sustainable supply chain management, and social responsibility. “The EcoVadis Platinum Medal is more than just an award — it is the recognition of our collective efforts to embed sustainable development principles at the heart of our corporate strategy and culture,” says Sylvaine Couleur, Executive Vice President, CSR & Communication. “Achieving this level demonstrates that our commitments are tangible, impactful, and internationally recognized. This distinction strengthens our determination to further advance and expand our C
In our pressroom you can read all our latest releases, find our press contacts, images, documents and other relevant information about us.
Visit our pressroom