STALLERGENES-GREER
Stallergenes Greer, a global healthcare company specialising in allergen immunotherapy (AIT), today announced that results of its EfficAPSI real-world study evaluating the impact of Stallergenes Greer liquid sublingual AIT (SLIT-liquid) on asthma onset and evolution in patients with allergic rhinitis have been published in the Lancet Regional Health-Europe. The publication is available online (https://doi.org/10.1016/j.lanepe.2024.100915) and will be available in print at a later date.
This retrospective longitudinal pharmaco-epidemiological real-world study, which evaluated data over a 9-year period, included over 440,000 patients: more than 110,000 patients with allergic rhinitis, with or without asthma, treated with Stallergenes Greer SLIT-liquid and symptomatic drugs; compared to more than 330,000 patients with allergic rhinitis, with or without asthma, treated with symptomatic drugs only.
The primary objective of the study was the evaluation of the real-world impact of Stallergenes Greer SLIT-liquid on the prevention of asthma onset or worsening in patients with allergic rhinitis. Study results were consistent across all age groups (patients above the age of 5), allergens and endpoints.
In patients undergoing treatment with Stallergenes Greer SLIT-liquid and symptomatic drugs versus patients treated with symptomatic drugs only, the study showed:
- a 36% reduction in the risk of new asthma events in the overall cohort*;
- a 38% reduction in the risk of asthma onset in patients without pre-existing asthma;
- a one-third reduction in Global Initiative for Asthma (GINA) treatment stepping-up, in patients with pre-existing asthma demonstrating the impact of SLIT-liquid to prevent asthma worsening.
“I am pleased that the publication of this extensive, large real-world EfficAPSI study in the Lancet Regional Health-Europe is now available for the medical community. The study confirms the role of SLIT- liquid in reshaping asthma management. The findings deliver important insights on the relevance of SLIT liquid as etiological medication which offers the advantage of a personalised treatment tailored to each patient's unique needs for improved outcomes,” said Professor Pascal Demoly, MD, PhD, Head of the Pulmonology, Allergology and Thoracic Oncology Department, Montpellier University Hospital (France), President of the French Society of Allergology, and member of the study’s scientific committee.
“Exploring the impact of allergen immunotherapy on asthma onset and progression is crucial, and we're committed to filling those gaps. Through this real-world EfficAPSI study, Stallergenes Greer is honoured to contribute valuable scientific evidence and insights to allergy treatment. We remain focused on advancing disease-modifying solutions, fuelled by strong clinical data, to redefine respiratory care, and dedicated to improving quality of life for people with allergies” declared Dr Elena Rizova, Chief Medical Officer, Stallergenes Greer.
By demonstrating the benefit on the onset and worsening of asthma, Stallergenes Greer SLIT-liquid treatments confirm their impact in terms of public health. Stallergenes Greer intends to increasingly use a real-world approach to bolster the evidence supporting the beneficial effects of SLIT. Additional endpoints are currently under evaluation and will be published subsequently.
ABOUT EfficAPSI 1
EfficAPSI is to date the largest retrospective real-world, longitudinal cohort study regarding liquid sublingual AIT. Its main objective was to evaluate the real-life impact of SLIT-liquid on the prevention of asthma onset and worsening in patients with allergic rhinitis. This study included more than 110,000 patients in France with allergic rhinitis, with or without asthma, treated with Stallergenes Greer SLIT-liquid and symptomatic drugs and more than 330,000 patients with allergic rhinitis, with or without asthma, treated with symptomatic drugs only. The EfficAPSI study, evaluated data from January 1, 2010 to December 31, 2018.
EfficAPSI is the first study in the AIT field in which the French national system database (SNDS), covering 99% of the French population, has been used to gain insight on therapeutic benefits in real life practice by pairing their data with the data of a healthcare company.
Onset or worsening of asthma were defined as the first occurrence of a specific pharmacy dispensation, hospitalisation or long-term disease (LTD) for asthma in the sensitive analysis; pharmacy dispensation was omitted for a more specific, secondary definition, focusing on severe forms of asthma. A combined definition, both sensitive and specific, was also used considering specific pharmacy dispensation of major medications (omalizumab or three inhaled corticosteroids associated or not with long-acting beta agonists), hospitalisation or LTD for severe asthma. Analyses were stratified on pre-existing mild or moderate asthma to differentiate between the onset and worsening of asthma.
A total of 112,492 exposed (SLIT-liquid) and 333,082 unexposed patients (control) were included.
Findings on new asthma events: in allergic rhinitis patients, Stallergenes Greer SLIT-Liquid exposure was associated with a significantly lower risk of new asthma events, when compared to control group (symptomatic drugs only), according to all definitions (sensitive, HR: 0.76, 95% CI 0.75-0.76; specific, HR: 0.66, 95% CI 0.63-0.69; combined, HR: 0.64, 95% CI 0.63-0.65).
Findings on onset of asthma: in allergic rhinitis patients without pre-existing asthma, Stallergenes Greer SLIT-liquid exposure was associated with a significantly lower risk of asthma onset when compared to control group (symptomatic drugs only), according to all definitions (sensitive, HR: 0.77, 95% CI 0.76-0.78; specific, HR: 0.67, 95% CI 0.61-0.72; combined, HR: 0.62, 95% CI 0.60-0.63).
Findings on worsening of asthma: in allergic rhinitis patients with pre-existing asthma, Stallergenes Greer SLIT-liquid exposure was associated with a significantly lower risk of asthma events when compared to control group (symptomatic drugs only), according to all definitions (sensitive, HR: 0.71, 95% CI 0.70-0.72; specific, HR: 0.62, 95% CI 0.59-0.65; combined, HR: 0.62, 95% CI 0.61-0.63). In addition, a one-third reduction in GINA treatment stepping-up was observed regardless of patients’ GINA treatment step at baseline (HR: 0.72, 95% CI 0.69-0.75 for baseline step 1; HR: 0.73, 95% CI 0.68-0.79 for baseline step 2; HR; 0.71, 95% CI 0·65-0·78 for baseline step 3/4).
The EfficAPSI study covers a wide range of allergens including house dust mites, grass, birch and ragweed pollens, and cat dander. Results were positive and consistent for all analysable allergens and all age groups (above the age of 5).
The study was designed with a scientific committee composed of Prof. Pascal Demoly, MD, PhD, HDR, Head of the Pulmonology, Allergology and Thoracic Oncology Department, Montpellier University Hospital (France); Prof. Philippe Devillier, Hôpital Foch, Suresnes (France); Prof. Jean François Bergmann, Head of Internal Medicine, Hôpital Lariboisière, Paris, Professor of Therapeutics, Paris-Diderot University (France); Dr. Bertrand Delaisi, Boulogne-Billancourt (France), and Prof. Mathieu Molimard, Head of the Pharmacology Department, Bordeaux University Hospital (France).
ABOUT ALLERGIC RHINITIS
Allergic rhinitis is a worldwide disease affecting more than 500 million people, who are at higher risk of developing rhinitis exacerbation and asthma than the general population. Allergic rhinitis can include symptoms such as sneezing, a runny or itchy nose, nasal congestion and watery or itchy eyes, among others.2,3 Symptoms may be severe and can worsen over time and have a significant impact on quality of life.2,4,5,6,7
ABOUT STALLERGENES GREER INTERNATIONAL AG
Headquartered in Baar (Switzerland), Stallergenes Greer International AG is a global healthcare company specialising in the diagnosis and treatment of respiratory, food and venom allergies through the development and commercialisation of allergen immunotherapy products and services. Stallergenes Greer International AG is the parent company of Greer Laboratories, Inc. (whose registered office is in the United States) and Stallergenes SAS (whose registered office is in France). For more information, visit www.stallergenesgreer.com.
*combined score
_______________________________
1 Demoly P, Molimard M, Bergmann JF, et al. Impact of liquid sublingual immunotherapy on asthma onset and progression in patients with allergic rhinitis: a nationwide population-based study (EfficAPSI study). Lancet Reg Health Eur. 2024. https://doi.org/10.1016/j.lanepe.2024.100915
2 Demoly P, Corren J, Creticos P, et al. A 300 IR sublingual tablet is an effective, safe treatment for house dust mite–induced allergic rhinitis: An international, double-blind, placebo-controlled, randomized phase III clinical trial. J Allergy Clin Immunol. 2021;147(3):1020-1030.e10
3 Bousquet J, Khaltaev N, Cruz A, et al. Allergic Rhinitis and its Impact on Asthma (ARIA) 2008 update (in collaboration with the World Health Organization, GA(2)LEN and AllerGen). Allergy. 2008 Apr;63 Suppl 86:8-160.
4 Brozek JL, Bousquet J, Agache I, Agarwal A, Bachert C, Bosnic-Anticevich S, et al. Allergic Rhinitis and its Impact on Asthma (ARIA) guidelines— 2016 revision. J Allergy Clin Immunol. 2017;140(4):950–8
5 Linneberg A., Henrik Nielsen N., Frolund L, et al. The link between allergic rhinitis and allergic asthma: a prospective population-based study. The Copenhagen Allergy Study. Allergy. 2002 Nov;57(11):1048-1052.
6 Shin J-W, Sue J-H, Song T-W, et al. Atopy and house dust mite sensitization as risk factors for asthma in children. Yonsei Med J.2005;46: 629- 634.
7 Hankin C. S., Cox L., Lang D., et al. Allergen immunotherapy and health care cost benefits for children with allergic rhinitis: a large-scale, retrospective, matched cohort study. Ann Allergy Asthma Immunol. 2010 Jan;104(1):79-85
To view this piece of content from cts.businesswire.com, please give your consent at the top of this page.
View source version on businesswire.com: https://www.businesswire.com/news/home/20240502732743/en/
About Business Wire
Subscribe to releases from Business Wire
Subscribe to all the latest releases from Business Wire by registering your e-mail address below. You can unsubscribe at any time.
Latest releases from Business Wire
Elegen and Nutcracker Therapeutics to Pilot First Fully Cell-Free Manufacturing Process for RNA-based Personalized Cancer Therapeutics11.7.2025 14:00:00 CEST | Press release
Fully cell-free process aims to further democratize personalized cancer therapeutic manufacturing with shorter turnaround times and negligible bioburden and endotoxin risks. Elegen, a global leader in next-generation DNA manufacturing, and Nutcracker Therapeutics, a global leader in next-generation RNA design and manufacturing, today announced the launch of a pilot program to demonstrate the industry’s first fully synthetic, cell-free manufacturing platform for RNA-based personalized cancer therapeutics (PCTs). The pilot marks another step toward making PCTs more accessible, timely, and scalable. This press release features multimedia. View the full release here: https://www.businesswire.com/news/home/20250711152688/en/ As late-stage PCT clinical trials progress and therapy developers work to create the next generation of PCTs, the speed, reliability, scaling and cost of traditional production methods pose a major challenge. Specifically, the first step of DNA template production is hi
$MBG Token Pre-Sale Set for July 15 — Only 7 Million Tokens Available at $0.3511.7.2025 10:17:00 CEST | Press release
MultiBank Group, the world’s largest financial derivatives institution headquartered in Dubai, has confirmed that its highly anticipated $MBG Token pre-sale will go live on July 15, with demand expected to be intense. This press release features multimedia. View the full release here: https://www.businesswire.com/news/home/20250711737311/en/ With only 7 million $MBG tokens up for grabs at an exclusive entry price of $0.35, this is a rare opportunity to secure early access to what many are calling the year’s most powerful utility asset. With only 7 million tokens up for grabs at an exclusive entry price of $0.35, this is a rare opportunity to secure early access to what many are calling the year’s most powerful utility asset. Early participants can join simultaneously on MultiBank.io, the Group’s regulated crypto exchange, and Uniswap, the world’s leading decentralized platform. Supported by $29 billion in real assets and powered by over $35 billion in daily turnover, $MBG is engineered
Live Story Raises €2.7 Million to Revolutionize the Digital Experience11.7.2025 10:05:00 CEST | Press release
With a round led by Vertis, the next-generation CMS platform accelerates its focus onAI, performance, and European expansion. Target: surpass €10M in recurring revenueby 2027. Live Story, the tech company founded by Stefano Mocellini, has closed a €2.7 million seed round led by Vertis, one of Italy’s leading early-growth venture capital firms. The funding will support the company’s international expansion and technological development, with a clear goal: to exceed €10 million in annual recurringrevenue by 2027. This press release features multimedia. View the full release here: https://www.businesswire.com/news/home/20250711335560/en/ “We invested in Live Story because it addresses one of the major inefficiencies in digital commerce: the slow and rigid management of visual and narrative content,” says Alessandro Pontari, Partner at Vertis SGR. “The platform helps brands drastically reduce their time-to-market through a visual CMS that integrates seamlessly with any tech stack. In a wor
With a Score of 84 out of 100, Sagemcom Is Awarded the EcoVadis Platinum Medal: a Prestigious Recognition of its CSR Commitment11.7.2025 09:00:00 CEST | Press release
Sagemcom Group is proud to announce that it has been awarded, for the third time, the Platinum Medal by EcoVadis, the highest distinction granted by the leading global platform for assessing Corporate Social Responsibility (CSR) performance. This medal places Sagemcom in the top 1% of companies evaluated worldwide, across all industries. With a score of 84 out of 100, Sagemcom reaffirms its position as a committed leader in ecological transition, business ethics, sustainable supply chain management, and social responsibility. “The EcoVadis Platinum Medal is more than just an award — it is the recognition of our collective efforts to embed sustainable development principles at the heart of our corporate strategy and culture,” says Sylvaine Couleur, Executive Vice President, CSR & Communication. “Achieving this level demonstrates that our commitments are tangible, impactful, and internationally recognized. This distinction strengthens our determination to further advance and expand our C
IEEE Standards Commitment to Advancing AI Governance Includes Impactful Contributions to New International AI Standards Exchange11.7.2025 08:00:00 CEST | Press release
IEEE, the world’s largest technical professional organization dedicated to advancing technology for humanity, and its IEEE Standards Association (IEEE SA) announced today that its portfolio of over 100 global AI-related standards is included in the new International AI Standards Exchange. This Exchange is a centralized repository of international AI standards with the aim to foster collaboration and responsible AI development worldwide. IEEE and its AI global standards were recognized in the 2024 United Nations AI Advisory Body’s Report, Governing AI for Humanity, which created the impetus for the AI Standards Exchange. Due to its impactful AI standards and related work, IEEE, a major standards body, was included as a partner in the establishment of the Exchange. IEEE President and CEO Kathleen Kramer, who is speaking at the AI for Good Summit this year at the High-Level AI Standards Panel,shares, “IEEE’s mission of advancing technology for the benefit of humanity is foundational to ou
In our pressroom you can read all our latest releases, find our press contacts, images, documents and other relevant information about us.
Visit our pressroom