GeneTex, Inc.
6.6.2023 15:05:40 CEST | ACCESS Newswire | Press release
IRVINE, CA / ACCESSWIRE / June 6, 2023 / GeneTex, a multinational antibody manufacturing company, is leveraging its recombinant monoclonal antibody production platform to produce best-in-class biomedical research reagents. The specificity of these new antibodies is established through meticulous in-house validation testing based on knockdown/knockout methodologies complemented by other strategies. GeneTex has employed this process to develop and thoroughly validate its new programmed death-ligand 1 (PD-L1) recombinant rabbit monoclonal antibody for immunohistochemistry (IHC).
The interaction between PD-L1 (CD274/B7-H1) and its receptor programmed death-1 (PD-1) is not only a focus of cancer immunotherapy research but also has major therapeutic relevance for many solid malignancies. PD-L1 is an immune checkpoint inhibitor that binds to PD-1 expressed on T cells and other effectors to quash immune system overactivation and autoimmunity. Cancer cells exploit this and overexpress PD-L1, creating an immunosuppressive state through induced cell death of anti-tumor T cells. Thus, gauging PD-L1 expression on tumor cells can identify cancers that may respond to anti-PD-L1/PD-1 agents. Given the importance of PD-L1 detection in patient tumor samples for both prognostic and treatment considerations, reliable reagents are clearly essential for both research and clinical decision-making.
Immunohistochemistry is utilized routinely in both academic and clinical settings to determine PD-L1 expression in both normal and cancerous tissues. GeneTex's recombinant rabbit monoclonal antibody (PD-L1 antibody [HL1041]) is a cited, PD-L1-specific, knockout-validated reagent that performs in three applications (i.e., western blot, immunocytochemistry, and IHC). To further evaluate this antibody's IHC capabilities, GeneTex enlisted the assistance of MS Validated Antibodies GmbH (MSVA), a company with demonstrated proficiency in IHC optimization that has assessed over 5000 antibodies for their functionality in formalin-fixed tissue IHC. MSVA completed an extensive analysis of the GeneTex antibody's staining on tumor samples and a broad array of normal tissues, comparing the signal to that of another well-established PD-L1 antibody (see Figure). GeneTex clone [HL1041] exhibited excellent sensitivity and specificity. Marco Sauter, MSVA CEO, commented, "As formalin fixation alters the structure and accessibility of many epitopes, a trustworthy antibody validation for IHC invariably requires the analysis of a very broad range of formalin-fixed tissues. Our analysis of more than 70 different normal tissue types and of a broad range of different cancers exceeds what regulatory agencies currently require. We are gratified that our MSVA approach could help to identify PD-L1 clone [HL1041] with binding properties that are comparable to the most established PD-L1 antibodies on the market."
The need for quality antibodies to visualize the expression of biomarkers crucial for cancer biology research and patient care remains vast, particularly for IHC. GeneTex is presently developing reagents against a number of key targets. Allen Lee, GeneTex's Vice President of Business Development, stressed the importance of expertise-based collaborations to create gold-standard products for scientists and clinicians: "GeneTex is excited to extend our partnership with MSVA. Their IHC validation services align perfectly with GeneTex's core mission, which is to provide the biomedical community with the highest quality immunological reagents supported by extensive research, development, and validation."
GeneTex products are for research use only. Not for diagnostic or therapeutic procedures.
Media Contact:
Allen Lee
Phone: 949.553.1900
Email: allensl@genetex.com
www.genetex.com
Contact Information
Allen Lee
Vice President - Business Development
allensl@genetex.com
(949)553-1900
SOURCE: GeneTex, Inc.
To view this piece of content from stats.newswire.com, please give your consent at the top of this page.View source version on accesswire.com:
https://www.accesswire.com/759287/GeneTex-Launches-PD-L1-Antibody-Comprehensively-Validated-by-MS-Validated-Antibodies-GmbH-for-Immunohistochemistry
To view this piece of content from www.accesswire.com, please give your consent at the top of this page.
About ACCESS Newswire
Subscribe to releases from ACCESS Newswire
Subscribe to all the latest releases from ACCESS Newswire by registering your e-mail address below. You can unsubscribe at any time.
Latest releases from ACCESS Newswire
Valsoft's TAG Software Group Acquires Positive Solutions, a UK Provider of Healthcare and Pharmacy Software15.10.2026 17:00:00 CEST | Press release
MONTRÉAL, QC / ACCESS Newswire / October 15, 2026 / Valsoft Corporation Inc. ("Valsoft"), a Canadian company specializing in the acquisition and long-term development of vertical market software businesses, today announced the acquisition of Positive Solutions Limited ("Positive Solutions"), a UK-based provider of pharmacy management and point-of-sale software for community pharmacies. The acquisition was completed through TAG Software Group, a wholly owned subsidiary of Valsoft. Founded in 1993 and headquartered in Adlington, UK, Positive Solutions provides integrated software that community pharmacies use to dispense medicine and run their retail operations. Its core products, Analyst PMR (patient medication record) and Analyst EPoS (electronic point of sale), support pharmacies ranging from single-site locations to large corporations. The company serves more than 2,500 sites across England, Scotland, and Wales. With this acquisition, TAG Software Group strengthens Valsoft's presence
OMP and Eastman Show Decision Velocity in Practice at Gartner Supply Chain Planning Summit 202615.10.2026 15:00:00 CEST | Press release
ATLANTA, GA / ACCESS Newswire / October 15, 2026 / OMP, a leader in AI-powered supply chain planning, is bringing Eastman to the Gartner Supply Chain Planning Summit 2026 in Denver, CO (November 2-3) to showcase decision velocity in practice. The global specialty materials company will show how it connected its long-term, mid-term, and short-term planning horizons into one cycle. Eastman on connecting its planning horizons In a session at the summit, Sachin Kothari, Manager IBP Excellence at Eastman, and Abhi Patel, Chief Business Operations Officer at OMP, will explain how Eastman moved from three planning horizons that each ran on their own schedule to one connected cycle linking long-, mid-, and short-term planning on a shared view of the value chain. The session also covers what got in the way of the shift and closes with the impact Eastman measured, along with recommendations for supply chain leaders whose planning still relies on handoffs. Meet OMP and explore planning transforma
Innodata to Report Third Quarter 2026 Results15.10.2026 14:05:00 CEST | Press release
NEW YORK, NY / ACCESS Newswire / October 15, 2026 / INNODATA INC. (Nasdaq:INOD) today announced that it will report Third Quarter 2026 results after the market closes on Thursday, November 5, 2026. A news release will be available in both the News and Investor Relations sections of the Innodata website, www.innodata.com. Innodata has scheduled an investor conference call for 5:00 PM Eastern time on that same day. The call-in numbers for the conference call are:(+1) 833 296 5777 North America, Toll Free(+44) 808 196 8935 United Kingdom(+1) 206 407 3228 InternationalParticipant Access Code 730 768 717 For Replay: (+1) 833 309 1852 North America-Toll Free(+44) 800 007 4044 United Kingdom(+1) 929 828 5978 InternationalAccess Code 730 768 717 Investors are also invited to access a live Webcast of the conference call at the Investor Relations section of Innodata's website at https://investor.innodata.com/events-and-presentations/. Please note that the Webcast feature will be in listen-only m
Karbon-X (OTCQB:KARX) Secures €1.88 Million (US$2.18 Million) in Net Trading Margin Through New European Low-Carbon Fuel Contracts15.10.2026 13:45:00 CEST | Press release
CALGARY, AB / ACCESS Newswire / October 15, 2026 / Karbon-X Corp. (OTCQB:KARX) ("Karbon-X" or the "Company"), a global carbon and environmental markets company, today announced that it has established new commercial capabilities and contracted activity across European low-carbon fuels and environmental markets during the first quarter of fiscal 2027. During the first quarter, Karbon‑X secured European low-carbon fuel contracts representing approximately €1.88 million (US$2.18 million) in net trading margin based on the agreed transaction economics. The Company has also secured additional contracted activity extending beyond fiscal 2027, supporting the continued development of its European business. Europe's decarbonization agenda is increasingly moving from broad policy objectives into sector-specific regulatory frameworks. The European Union's Renewable Energy Directive, together with related sector-specific regulations, is accelerating demand for renewable and low-carbon energy and s
Nigeria Is the World's Next Outsourcing Frontier, Vice President Shettima Says at Hire From Nigeria Global Launch14.10.2026 23:50:00 CEST | Press release
NEW YORK, NY / ACCESS Newswire / October 14, 2026 / Nigeria is ready to meet the world's growing demand for talent, with an initial target of one million export-linked jobs by 2030, Vice President Kashim Shettima, GCON, said at the global launch of the Hire From Nigeria campaign. The launch was held in New York on 24 September, on the sidelines of the 81st session of the United Nations General Assembly. In a keynote address delivered on his behalf by the Deputy Chief of Staff to the President, Senator Ibrahim Hassan Hadejia, the Vice President said: "While much of the industrialized world grows older, and quietly wonders who will fill the productivity vacuum, Nigeria produces, every single year, a new generation of digitally fluent, English-speaking, ambitious young men and women, ready to serve the world from the home front and from a time zone that is convenient for almost every continent." He added: "The global market for outsourced services will be worth over a trillion dollars in
In our pressroom you can read all our latest releases, find our press contacts, images, documents and other relevant information about us.
Visit our pressroom