BOEHRINGER-INGELHEIM
9.5.2023 14:36:33 CEST | Business Wire | Press release
Boehringer Ingelheim announced today that it has launched clinical development of its first-in-class IL-11 inhibitor antibody BI 765423 with a Phase 1 study (NCT05658107) to assess the safety, tolerability, and pharmacokinetics in healthy volunteers. Boehringer Ingelheim is already a global leader in the treatment of pulmonary fibrosis, and the initiation of clinical development of the anti-IL-11 treatment reflects the company’s long-term commitment to combat fibrotic disease across therapeutic areas. The IL-11 inhibitor antibody is the first of its kind to reach clinical development stage and is based on a partnership between the Company and Enleofen Bio Pte. Ltd. (Enleofen), with a goal to improve patient outcomes.
‘Fibrotic disease’ is a term that covers a range of diseases characterized by uncontrolled and progressive fibrosis, or scarring, of various organs and tissues. It can be triggered by different factors (such as infections, inflammation, autoimmune disorders, degenerative diseases, tumors, and injury), can cause organ dysfunction/failure, and affect the quality of life and survival of patients. Some examples of fibrotic diseases are, systemic sclerosis, graft-versus-host disease as well as heart, lung, liver, and kidney fibrosis. Current treatments have led to progress in some areas, however fibrotic diseases remain to be a leading cause of morbidity/mortality and account for more than one third of deaths worldwide.
IL-11 plays a key role in fibrosis across multiple organs and pre-clinical studies have shown that anti-IL-11 treatment has the potential to stop – and even reverse fibrosis – in different fibrotic diseases. Boehringer Ingelheim joined forces with Enleofen, a leader in IL-11 biology, in 2020.
“The initiation of this trial is an important milestone for Boehringer Ingelheim and brings us closer to achieving our aim of transforming lives of people living with fibrotic diseases,” said Clive R. Wood, Ph.D., Corporate Senior Vice President and Global Head of Discovery Research at Boehringer Ingelheim. “The effects shown for anti-IL-11 preclinically are impressive and could, if confirmed in the clinic, herald a dramatic advance in the treatment of fibrotic diseases.”
“Enleofen is very excited to see the IL-11 inhibitor partnership with Boehringer Ingelheim, a leader in anti-fibrotic therapy R&D, moving forward into the clinic to address unmet patient needs,” said Prof Stuart Cook, co-founder of Enleofen and Tanoto Foundation Professor of Cardiovascular Medicine at the SingHealth Duke-NUS Academic Medical Centre and the Cardiovascular & Metabolic Disorders Programme at Duke-NUS Medical School, Singapore.
The IL-11 program complements Boehringer Ingelheim’s clinical fibrotic disease pipeline portfolio which includes BI 1015550, a phosphodiesterase 4B (PDE4B) inhibitor, under investigation in two Phase III randomized, double-blind, placebo-controlled trials—FIBRONEER™-IPF (NCT05321069) and FIBRONEER™-ILD (NCT05321082)—to investigate the efficacy, safety and tolerability of BI 1015550 over at least 52 weeks in patients with IPF and in patients with other progressive fibrosing ILDs and several other clinical stage programs.
###
About Boehringer Ingelheim
Boehringer Ingelheim is working on breakthrough therapies that transform lives, today and for generations to come. As a leading research-driven biopharmaceutical company, the company creates value through innovation in areas of high unmet medical need. Founded in 1885 and family-owned ever since, Boehringer Ingelheim takes a long-term, sustainable perspective. More than 53,000 employees serve over 130 markets in the two business units Human Pharma and Animal Health. Learn more at www.boehringer-ingelheim.com
About Enleofen
Enleofen is a Singapore-based biotech company developing first-in-class antibody therapeutics for the treatment of fibro-inflammatory human diseases. The initial discovery science and drug target validation was carried out by founders Stuart Cook and Sebastian Schäfer at the National Heart Centre Singapore at SingHealth and Duke-NUS Medical School and was subsequently licensed to Enleofen. Since 2017, the company has invested extensively in target validation, drug development, and preclinical studies, with the support of experienced international life sciences executives and investors, including founding directors Jeffrey Lu and Andrew Khoo.
To view this piece of content from cts.businesswire.com, please give your consent at the top of this page.
View source version on businesswire.com: https://www.businesswire.com/news/home/20230509005762/en/
About Business Wire
Subscribe to releases from Business Wire
Subscribe to all the latest releases from Business Wire by registering your e-mail address below. You can unsubscribe at any time.
Latest releases from Business Wire
Chiesi Appoints David Khougazian as Group Chief Executive Officer to Lead the Next Phase of Innovation-Driven Growth15.9.2026 11:00:00 CEST | Press release
Highlights: David Khougazian appointed Group Chief Executive Officer to lead Chiesi's next phase of innovation-driven growth, effective 15 October 2026. Bringing over 25 years of international healthcare leadership experience and a strong track record in innovation and transformation, David joins Chiesi from Flagship Pioneering. Chiesi Group (Chiesi) today announced the appointment of David Khougazian as Group Chief Executive Officer (CEO), effective 15 October 2026. David joins Chiesi following a distinguished international career spanning more than 25 years across the global healthcare and life sciences sectors. Most recently, he served as Executive Partner, Growth, and Head of Global Engagement at Flagship Pioneering, where he supported the growth and development of science-driven healthcare companies and worked closely with leadership teams on long-term value creation, partnerships, financing and organizational development. Following a thorough selection process led by the Board of
TOYO Corporation Opens Its Quantum Computers to Japan's Ecosystem15.9.2026 10:32:00 CEST | Press release
IQM Spark is TOYO's second quantum computer purchase, following its earlier acquisition of an IQM Radiance 20-qubit quantum computer. IQM will deliver both systems by the end of 2026. Both systems will be operational in early 2027 — the Spark system at TOYO's R&D center, and the Radiance 20 at AIST's Global Research and Development Center for Business by Quantum-AI technology (G-QuAT). TOYO will leverage the quantum infrastructure for its quantum initiatives, while extending access to Japan's wider quantum ecosystem. The move directly supports Japan's national quantum strategy, which targets 10 million domestic quantum users and ¥50 trillion in quantum-generated economic value by 2030. The deployments extend IQM's installed base across Asia-Pacific, following systems already delivered in South Korea and Taiwan. They also follow IQM's Nasdaq listing and an order backlog that has grown past €102 million. IQM Quantum Computers, a global leader in superconducting quantum computers, today a
Smartstream Further Enables Collateral Teams with Instant Answers and Controlled Automation through New MCP Servers15.9.2026 10:00:00 CEST | Press release
Key Facts Smart Collateral helps financial institutions manage the complete margin and collateral lifecycle, providing the control, visibility and governance required to operate at scale. Teams can now interact with that information in plain language, getting answers on agreements, eligibility, positions, margin calls and interest calculations without navigating multiple screens and reports across separate systems. Workflow actions, including creating or failing movements and issuing margin calls, are opt-in, so each firm decides exactly what an AI assistant is permitted to do. Two Model Context Protocol servers connect any MCP-compatible AI assistant to Smart Collateral: one for operating the platform’s APIs, one read-only over the reporting database. Smartstream, the trusted data solutions provider for leading global financial institutions and enterprises, today announces two new Model Context Protocol (MCP) servers for Smart Collateral, enabling dynamic, agentic collateral operation
More Than Half of Global Businesses Want Greater Control Over Their Data in Latest Digital Sovereignty Push, According to Expereo15.9.2026 10:00:00 CEST | Press release
The findings highlight the growing role of network visibility in digital sovereignty strategies as enterprises navigate increasingly complex cloud, AI and connectivity environments Businesses around the world are seeking greater control over their data as growing concerns around AI, security and compliance push digital sovereignty higher up the boardroom agenda, according to the latest IDC InfoBrief commissioned by Expereo*. More than half (53%) of enterprises say they want greater control over sensitive and strategic data, while 33% of global organizations now view digital sovereignty as a top or high priority. The research also found that 30% rank it among the leading drivers of technology investment, highlighting how governance, risk and compliance considerations are becoming increasingly important as organisations scale AI and cloud initiatives. The findings suggest organizations are looking beyond traditional approaches to data governance as they seek to better manage risk, regula
SES and Elveo Mobile Deepen Collaboration to Advance Direct-to-Device Services in Europe15.9.2026 09:30:00 CEST | Press release
SES, a global leader in space solutions, and Elveo Mobile, the company that delivers mobile connectivity and elevated intelligence for a planet on the move, today announced the expansion of their collaboration to accelerate delivery of direct-to-device (D2D) services in Europe. This press release features multimedia. View the full release here: https://www.businesswire.com/news/home/20260915183604/en/ SES and Elveo Mobile Deepen Collaboration to Advance Direct-to-Device Services in Europe SES will leverage Elveo’s patented, proven and cost-effective D2D technology to enable seamless mobile roaming capabilities for European consumers, businesses, governments, institutional, and defense users. To further this vision, SES and Elveo Mobile will collaborate to establish manufacturing capabilities and a robust supply chain in Europe for the productions of the Low-Earth Orbit (LEO) D2D satellites, using Elveo’s patented D2D satellite bus, payload and software technology stack. These LEO D2D s
In our pressroom you can read all our latest releases, find our press contacts, images, documents and other relevant information about us.
Visit our pressroom